Abstract
Penicillin sulfoxides are converted to 3-halo-3-methylcepham-4-carboxylic acid esters or the corresponding cephem derivatives by heating the penicillin sulfoxide precursor in the polyhaloalkane solvent in the presence of an equimolar amount of a neutral or basic catalyst, respectively. Basic catalysts such as pyridine or 4-picoline afford cephem derivatives, whereas the quaternary ammonium salts bring about the formation of 3-halocepham derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 2887-2890 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 42 |
| Issue number | 17 |
| DOIs | |
| State | Published - 1 Aug 1977 |
| Externally published | Yes |