Rationally designed peptide regulators of protein kinase C

Eric N. Churchill; Nir Qvit; Daria Mochly-Rosen

doi:10.1016/j.tem.2008.10.002

Rationally designed peptide regulators of protein kinase C

Eric N. Churchill, Nir Qvit, Daria Mochly-Rosen

Stanford University

Research output: Contribution to journal › Review article › peer-review

88 Scopus citations

Abstract

Protein-protein interactions sequester enzymes close to their substrates. Protein kinase C (PKC) is one example of a ubiquitous signaling molecule with effects that are dependent upon localization. Short peptides derived from interaction sites between each PKC isozyme and its receptor for activated C kinase act as highly specific inhibitors and have become available as selective drugs in basic research and animal models of human diseases, such as myocardial infarction and hyperglycemia. Whereas the earlier inhibitory peptides are highly specific, we believe that peptides targeting additional interactions between PKC and selective substrates will generate even more selective tools that regulate different functions of individual isozymes. Here, we discuss the methodologies and applications for identifying selective regulators of PKC.

Original language	English
Pages (from-to)	25-33
Number of pages	9
Journal	Trends in Endocrinology and Metabolism
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.tem.2008.10.002
State	Published - Jan 2009
Externally published	Yes

Bibliographical note

Funding Information:
D.M.-R. is the founder of KAI Pharmaceuticals, a company that plans to bring PKC regulators to the clinic. However, none of the work in her lab is supported by the company.

Funding

D.M.-R. is the founder of KAI Pharmaceuticals, a company that plans to bring PKC regulators to the clinic. However, none of the work in her lab is supported by the company.

Funders	Funder number
National Institutes of Health	HL76670, HL52141
National Institute on Alcohol Abuse and Alcoholism	R01AA011147

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2008.10.002

Cite this

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Rationally designed peptide regulators of protein kinase C

Abstract

Bibliographical note

Funding

UN SDGs

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