TY - JOUR
T1 - Rare variants of head and neck squamous cell carcinoma –differential immunohistochemical profiles
AU - Allon, Irit
AU - Vered, Marilena
AU - Kaplan, Ilana
AU - Nahlieli, Oded
AU - Yahalom, Ran
AU - Shalmon, Bruria
AU - Srouji, Samer
AU - Livoff, Alejandro
N1 - Publisher Copyright:
© 2019
PY - 2019/11
Y1 - 2019/11
N2 - We aimed to immunohistochemically characterize the pattern of expression of epithelial markers in rare head and neck squamous cell carcinoma (HNSCC) variants: carcinoma cuniculatum (CC) and adenosquamous carcinoma (ASC). We also present an additional variant of HNSCC with concomitant basaloid and squamous components that has overlapping morphological features with odontogenic and non-odontogenic tumors, which we termed basalo-squamous carcinoma (BSC). The selected markers included CK5/6, p40, CK19, BerEP4, p16 and SOX10. All tumors were CK5/6 and p40 positive. CK19 and BerEP4 were positive in BSC and focally in ASC but negative in CC. p16 was positive in 3 (60%) of the CCs, focally positive in ASC and negative in BSC. SOX10 was negative in all three variants. Our results highlight the plasticity of the lining epithelium revealing differential profiles of immuno-expression of the selected molecular markers, possibly reflecting their diverse histopathogenesis.
AB - We aimed to immunohistochemically characterize the pattern of expression of epithelial markers in rare head and neck squamous cell carcinoma (HNSCC) variants: carcinoma cuniculatum (CC) and adenosquamous carcinoma (ASC). We also present an additional variant of HNSCC with concomitant basaloid and squamous components that has overlapping morphological features with odontogenic and non-odontogenic tumors, which we termed basalo-squamous carcinoma (BSC). The selected markers included CK5/6, p40, CK19, BerEP4, p16 and SOX10. All tumors were CK5/6 and p40 positive. CK19 and BerEP4 were positive in BSC and focally in ASC but negative in CC. p16 was positive in 3 (60%) of the CCs, focally positive in ASC and negative in BSC. SOX10 was negative in all three variants. Our results highlight the plasticity of the lining epithelium revealing differential profiles of immuno-expression of the selected molecular markers, possibly reflecting their diverse histopathogenesis.
KW - Adenosquamous carcinoma
KW - Carcinoma cuniculatum
KW - Carcinoma with basaloid and squamous components
KW - Head and neck squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85072268321&partnerID=8YFLogxK
U2 - 10.1016/j.acthis.2019.151444
DO - 10.1016/j.acthis.2019.151444
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C2 - 31548087
AN - SCOPUS:85072268321
SN - 0065-1281
VL - 121
JO - Acta Histochemica
JF - Acta Histochemica
IS - 8
M1 - 151444
ER -