Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

David D. Ho; Avidan U. Neumann; Alan S. Perelson; Wen Chen; John M. Leonard; Martin Markowitz

doi:10.1038/373123a0

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

David D. Ho, Avidan U. Neumann, Alan S. Perelson, Wen Chen, John M. Leonard, Martin Markowitz

Research output: Contribution to journal › Article › peer-review

3869 Scopus citations

Abstract

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 ±0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	Nature
Volume	373
Issue number	6510
DOIs	https://doi.org/10.1038/373123a0
State	Published - 12 Jan 1995
Externally published	Yes

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AU - Markowitz, Martin

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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

Abstract

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