TY - JOUR
T1 - Radiolabeled 75Se-silica nanoparticles
T2 - synthesis, characterization and coating with ω-functionalized alkylsilane compounds
AU - Brandriss, S.
AU - Borchardt, G.
AU - Kreuter, J.
AU - Margel, S.
PY - 1995/6
Y1 - 1995/6
N2 - The synthesis and characterization of new radiolabeled 75Se-silica nanoparticles are described. These particles have been prepared by dispersion polymerization of tetraethylorthosilicate in ethanol in presence of radiolabeled 75selenium-colloids. The amount of Se-colloids encapsulated within the silica matrix was then increased by two successive seeded polymerizations of tetraethylorthosilicate on the previously formed particles. Kinetic studies and the effect of various factors, i.e. sodium selenite, water and ammonium hydroxide concentrations, on the diameter of these nanoparticles have been elucidated. The Se-silica nanoparticles have been covalently coated by the self-assembled technique with a variety of ω-functionalized alkylsilane compounds. Characterization of these coatings has been performed by Fourier transform-infrared spectroscopy, elemental analysis and floatability studies. The potential use of these varieties of ω-functionalized radiolabeled nanoparticles for drug delivery purposes has been demonstrated in a separate article.
AB - The synthesis and characterization of new radiolabeled 75Se-silica nanoparticles are described. These particles have been prepared by dispersion polymerization of tetraethylorthosilicate in ethanol in presence of radiolabeled 75selenium-colloids. The amount of Se-colloids encapsulated within the silica matrix was then increased by two successive seeded polymerizations of tetraethylorthosilicate on the previously formed particles. Kinetic studies and the effect of various factors, i.e. sodium selenite, water and ammonium hydroxide concentrations, on the diameter of these nanoparticles have been elucidated. The Se-silica nanoparticles have been covalently coated by the self-assembled technique with a variety of ω-functionalized alkylsilane compounds. Characterization of these coatings has been performed by Fourier transform-infrared spectroscopy, elemental analysis and floatability studies. The potential use of these varieties of ω-functionalized radiolabeled nanoparticles for drug delivery purposes has been demonstrated in a separate article.
KW - Alkylsilane nanoparticles
KW - Coatings
KW - Radiolabeled microspheres
KW - Radiolabeled nanoparticles
KW - Se-S, nanoparticles/microspheres
UR - http://www.scopus.com/inward/record.url?scp=0029325019&partnerID=8YFLogxK
U2 - 10.1016/0923-1137(94)00095-M
DO - 10.1016/0923-1137(94)00095-M
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AN - SCOPUS:0029325019
SN - 1381-5148
VL - 25
SP - 111
EP - 125
JO - Reactive and Functional Polymers
JF - Reactive and Functional Polymers
IS - 2-3
ER -