Quaternary ammonium polyethylenimine nanoparticles for treating bacterial contaminated water

Shady Farah, Oren Aviv, Natalia Laout, Stanislav Ratner, Nurit Beyth, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


This study highlights the potential application of antimicrobial quaternary ammonium nanomaterials for water disinfection. Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles (NPs) were synthesized by polyethylenimine crosslinking and alkylation with octyl iodide followed by methyl iodide quaternization. Particles modified with octyldodecyl alkyl chains were also prepared and evaluated. The antimicrobial activity of QA-PEI NPs was studied after anchoring in non-leaching polymeric coatings and also in aqueous suspension. Particles at different loadings (w/w) were embedded in polyethylene vinyl acetate and polyethylene methacrylic acid coatings and tested for antimicrobial activity against four representative strains of bacteria in static and dynamic modes. Coatings embedded with fluorescent labelled particles tracked by Axioscope fluorescence microscope during the antimicrobial test indicates no particles leaching out. Coatings loaded with 5% w/w QA-PEI exhibited strong antibacterial activity. Aqueous suspension was tested and found effective for bacterial decontamination at 0.1. ppm and maintains its activity for several weeks.

Original languageEnglish
Pages (from-to)614-619
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
StatePublished - 1 Apr 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.


  • Antimicrobial nanoparticles
  • Antimicrobial surface
  • Polyethylenimine
  • Water disinfection


Dive into the research topics of 'Quaternary ammonium polyethylenimine nanoparticles for treating bacterial contaminated water'. Together they form a unique fingerprint.

Cite this