Quaternary ammonium poly(diethylaminoethyl methacrylate) possessing antimicrobial activity

Shady Farah, Oren Aviv, Natalia Laout, Stanislav Ratner, Nurit Beyth, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Quaternary ammonium (QA) methacrylate monomers and polymers were synthesized from a N-alkylation of N,. N-diethylaminoethyl methacrylate (DEAEM) monomer. Linear copolymers, and for the first time reported crosslinked nanoparticles (NPs), based QA-PDEAEM were prepared by radical polymerization of the quaternized QA-DEAEM monomers with either methyl methacrylate (MMA) or a divinyl monomer.QA-PDEAEM NPs of 50-70nm were embedded in polyethylene vinyl acetate coating. QA-polymers with N-C8 and N-C18 alkyl chains and copolymers with methyl methacrylate were prepared at different molar ratios and examined for their antimicrobial effectiveness. These coatings exhibited strong antibacterial activity against four representative Gram-positive and Gram-negative bacteria.

Original languageEnglish
Pages (from-to)608-613
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
StatePublished - 1 Apr 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.


  • Antimicrobial nanoparticles
  • Antimicrobial surfaces
  • Diethylaminoethyl methacrylate
  • Quaternary ammonium (QA) polymers


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