Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Michelle K. Manske; Neta S. Zuckerman; Michael M. Timm; Stephanie Maiden; Hanna Edelman; Gitit Shahaf; Michal Barak; Angela Dispenzieri; Morie A. Gertz; Ramit Mehr; Roshini S. Abraham

doi:10.1016/j.clim.2006.01.008

Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Michelle K. Manske, Neta S. Zuckerman, Michael M. Timm, Stephanie Maiden, Hanna Edelman, Gitit Shahaf, Michal Barak, Angela Dispenzieri, Morie A. Gertz, Ramit Mehr, Roshini S. Abraham

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies. © 2006 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	106-120
Number of pages	15
Journal	Clinical Immunology
Volume	120
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2006.01.008
State	Published - 1 Jan 2006

Bibliographical note

Funding Information:
The authors would like to acknowledge the following sources of financial support for this study, the Hematological Malignancies Research Fund, Mayo Foundation (RSA); The Israel Science Foundation (grant number 759/01-1), the Israel Cancer Research Fund, the Human Frontiers Science Program, and the Swedish Foundation for Strategic Research (RM). The authors would also acknowledge the Mayo Dysproteinemia Cell Bank for providing BM and blood samples for the AL and MM patients. The authors thank Ms. Lavonne Knutson for the assistance with manuscript preparation.

Keywords

B cells
Clone
Human
Immunoglobulin light chain amyloidosis
Monoclonal gammopathy
Plasma cell dyscrasia

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Manske, M. K., Zuckerman, N. S., Timm, M. M., Maiden, S., Edelman, H., Shahaf, G., Barak, M., Dispenzieri, A., Gertz, M. A., Mehr, R., & Abraham, R. S. (2006). Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. Clinical Immunology, 120(1), 106-120. https://doi.org/10.1016/j.clim.2006.01.008

Manske, Michelle K. ; Zuckerman, Neta S. ; Timm, Michael M. et al. / Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis : Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. In: Clinical Immunology. 2006 ; Vol. 120, No. 1. pp. 106-120.

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abstract = "Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies. {\textcopyright} 2006 Elsevier Inc. All rights reserved.",

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Manske, MK, Zuckerman, NS, Timm, MM, Maiden, S, Edelman, H, Shahaf, G, Barak, M, Dispenzieri, A, Gertz, MA, Mehr, R & Abraham, RS 2006, 'Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis', Clinical Immunology, vol. 120, no. 1, pp. 106-120. https://doi.org/10.1016/j.clim.2006.01.008

Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. / Manske, Michelle K.; Zuckerman, Neta S.; Timm, Michael M. et al.
In: Clinical Immunology, Vol. 120, No. 1, 01.01.2006, p. 106-120.

Research output: Contribution to journal › Article › peer-review

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AU - Shahaf, Gitit

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Manske MK, Zuckerman NS, Timm MM, Maiden S, Edelman H, Shahaf G et al. Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. Clinical Immunology. 2006 Jan 1;120(1):106-120. doi: 10.1016/j.clim.2006.01.008

Quantitative analysis of clonal bone marrow CD19+ B cells: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis: Use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis

Abstract

Bibliographical note

Keywords

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