Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series

C. K. Peng, Shlomo Havlin, H. Eugene Stanley, Ary L. Goldberger

Research output: Contribution to journalArticlepeer-review

3122 Scopus citations


The healthy heartbeat is traditionally thought to be regulated according to the classical principle of homeostasis whereby physiologic systems operate to reduce variability and achieve an equilibrium-like state [Physiol. Rev. 9, 399-431 (1929)]. However, recent studies [Phys. Rev. Lett. 70, 1343-1346 (1993); Fractals in Biology and Medicine (Birkhauser-Verlag, Basel, 1994), pp. 55-65] reveal that under normal conditions, beat-to-beat fluctuations in heart rate display the kind of long-range correlations typically exhibited by dynamical systems far from equilibrium [Phys. Rev. Lett. 59, 381-384 (1987)]. In contrast, heart rate time series from patients with severe congestive heart failure show a breakdown of this long-range correlation behavior. We describe a new method - detrended fluctuation analysis (DFA) - for quantifying this correlation property in non-stationary physiological time series. Application of this technique shows evidence for a crossover phenomenon associated with a change in short and long-range scaling exponents. This method may be of use in distinguishing healthy from pathologic data sets based on differences in these scaling properties.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
Issue number1
StatePublished - 1995


Dive into the research topics of 'Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series'. Together they form a unique fingerprint.

Cite this