Pyridoxal-thiosemicarbazide: Its anion sensing ability and application in living cells imaging

Darshna Sharma, Anuradha Moirangthem, Rajender Kumar, S. K. Ashok Kumar, Anil Kuwar, John F. Callan, Anupam Basu, Suban K. Sahoo

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A new anion selective chemosensor L was derived through a direct condensation reaction between pyridoxal and thiosemicarbazide. Sensor L showed selective recognition and sensing ability towards F- and AcO- anions through a naked-eye detectable color change from colorless to light yellow, appearance of a new charge transfer absorption band at 404 nm and significant "turn-on" fluorescence at 506 nm. The detection limit of L as a fluorescent 'turn-on' sensor for the analysis of F- and AcO- was estimated to be 0.10 μM. The anion sensing mechanisms of L was supported by 1H NMR and DFT results. Finally, the cytotoxicity effect of L and its ability to image intracellular F- ions in the living HeLa cells was investigated.

Original languageEnglish
Pages (from-to)50741-50746
Number of pages6
JournalRSC Advances
Issue number63
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2015.


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