Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats

G. Grant; S. Bardocz; S. W.B. Ewen; D. S. Brown; T. J. Duguid; A. Pusztai; D. Avichezer; D. Sudakevitz; A. Belz; N. C. Garber; N. Gilboa-Garber

doi:10.1016/0928-8244(95)00025-3

Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats

G. Grant
, S. Bardocz
, S. W.B. Ewen
, D. S. Brown
, T. J. Duguid
, A. Pusztai
, D. Avichezer
, D. Sudakevitz
, A. Belz
, N. C. Garber
, N. Gilboa-Garber

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.

Original language	English
Pages (from-to)	191-195
Number of pages	5
Journal	FEMS Immunology and Medical Microbiology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0928-8244(95)00025-3
State	Published - Jun 1995

Bibliographical note

Funding Information:
G.G. gratefully acknowledgetsh e receipt of a British Council/Israeli Ministry of SciencesP ost-doctoralS cholarshipT. his work was supportedb y the ScottishO ffice Agriculturea ndF isheriesD epart-ment,t he Mitzi-Dobrin CancerR esearchF und and theH ealthS ciencesC entero f theD epartmenotf Life Scienceso f Bar-IlanU niversity.

Funding

G.G. gratefully acknowledgetsh e receipt of a British Council/Israeli Ministry of SciencesP ost-doctoralS cholarshipT. his work was supportedb y the ScottishO ffice Agriculturea ndF isheriesD epart-ment,t he Mitzi-Dobrin CancerR esearchF und and theH ealthS ciencesC entero f theD epartmenotf Life Scienceso f Bar-IlanU niversity.

Funders
Mitzi-Dobrin
ScottishO ffice Agriculturea

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Epithelium
Gut
Lectin
Pseudomonas aeruginosa
Rat

Access to Document

10.1016/0928-8244(95)00025-3

Cite this

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title = "Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats",

abstract = "The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.",

keywords = "Epithelium, Gut, Lectin, Pseudomonas aeruginosa, Rat",

author = "G. Grant and S. Bardocz and Ewen, \{S. W.B.\} and Brown, \{D. S.\} and Duguid, \{T. J.\} and A. Pusztai and D. Avichezer and D. Sudakevitz and A. Belz and Garber, \{N. C.\} and N. Gilboa-Garber",

note = "Funding Information: G.G. gratefully acknowledgetsh e receipt of a British Council/Israeli Ministry of SciencesP ost-doctoralS cholarshipT. his work was supportedb y the ScottishO ffice Agriculturea ndF isheriesD epart-ment,t he Mitzi-Dobrin CancerR esearchF und and theH ealthS ciencesC entero f theD epartmenotf Life Scienceso f Bar-IlanU niversity.",

year = "1995",

month = jun,

doi = "10.1016/0928-8244(95)00025-3",

language = "אנגלית",

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AU - Bardocz, S.

AU - Ewen, S. W.B.

AU - Brown, D. S.

AU - Duguid, T. J.

AU - Pusztai, A.

AU - Avichezer, D.

AU - Sudakevitz, D.

AU - Belz, A.

AU - Garber, N. C.

AU - Gilboa-Garber, N.

N1 - Funding Information: G.G. gratefully acknowledgetsh e receipt of a British Council/Israeli Ministry of SciencesP ost-doctoralS cholarshipT. his work was supportedb y the ScottishO ffice Agriculturea ndF isheriesD epart-ment,t he Mitzi-Dobrin CancerR esearchF und and theH ealthS ciencesC entero f theD epartmenotf Life Scienceso f Bar-IlanU niversity.

PY - 1995/6

Y1 - 1995/6

N2 - The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.

AB - The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.

KW - Epithelium

KW - Gut

KW - Lectin

KW - Pseudomonas aeruginosa

KW - Rat

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JO - FEMS Immunology and Medical Microbiology

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IS - 3

ER -

Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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