Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats

G. Grant, S. Bardocz, S. W.B. Ewen, D. S. Brown, T. J. Duguid, A. Pusztai, D. Avichezer, D. Sudakevitz, A. Belz, N. C. Garber, N. Gilboa-Garber

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations


    The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.

    Original languageEnglish
    Pages (from-to)191-195
    Number of pages5
    JournalFEMS Immunology and Medical Microbiology
    Issue number3
    StatePublished - Jun 1995

    Bibliographical note

    Funding Information:
    G.G. gratefully acknowledgetsh e receipt of a British Council/Israeli Ministry of SciencesP ost-doctoralS cholarshipT. his work was supportedb y the ScottishO ffice Agriculturea ndF isheriesD epart-ment,t he Mitzi-Dobrin CancerR esearchF und and theH ealthS ciencesC entero f theD epartmenotf Life Scienceso f Bar-IlanU niversity.


    • Epithelium
    • Gut
    • Lectin
    • Pseudomonas aeruginosa
    • Rat


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