PSF and p54nrb/NonO - Multi-functional nuclear proteins

Yaron Shav-Tal, Dov Zipori

Research output: Contribution to journalShort surveypeer-review

288 Scopus citations


Proteins are often referred to in accordance with the activity with which they were first associated or the organelle in which they were initially identified. However, a variety of nuclear factors act in multiple molecular reactions occurring simultaneously within the nucleus. This review describes the functions of the nuclear factors PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54nrb/NonO. PSF was initially termed a splicing factor due to its association with the second step of pre-mRNA splicing while p54nrb/NonO was thought to participate in transcriptional regulation. Recent evidence shows that the simplistic categorization of PSF and its homolog p54nrb/NonO to any single nuclear activity is not possible and in fact these proteins exhibit multi-functional characteristics in a variety of nuclear processes.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalFEBS Letters
Issue number2
StatePublished - 6 Nov 2002
Externally publishedYes


  • DNA pairing
  • Nucleus
  • Pre-mRNA splicing
  • RNA retention
  • TLS
  • Transcription


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