Protochordate concordant xenotransplantation settings reveal outbreaks of donor cells and divergent life span traits

Noa Simon-Blecher; Yair Achituv; Baruch Rinkevich

doi:10.1016/j.dci.2004.04.003

Protochordate concordant xenotransplantation settings reveal outbreaks of donor cells and divergent life span traits

Noa Simon-Blecher, Yair Achituv, Baruch Rinkevich

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

If fulminate rejection in allogeneic and xenogeneic engraftments is not an evolutionary relict feature, then any treatment that ablates the host surveillance's effector arms capabilities and eliminates graft vs. host reactivity should induce donor chimerism in transplant settings. We demonstrate here marked proliferative response of Botryllus (Urochordata) blood cells months following their infusions (2×10⁴-10⁵ blood cells per host) into the concordant xenogeneic environment of irradiated Botrylloides soma. The state of infused cells was followed by Botryllus specific microsatellite alleles on DNA samples from host zooids and vascular system. Increased growth rates and life spans of engrafted hosts in some cases, and sudden chimerical death following the outbreak of donor cells in others, indicate a 'double-edged sword' expression of concurrent evolutionary selected mechanisms. This DES phenomenon in immunity underlies divergent stem cell competition phenomena in multicellular organisms, leading in mammals, to cases of autoimmune diseases vis-à-vis long-lasting microchimerism events following an iatrogenic transplantation.

Original language	English
Pages (from-to)	983-991
Number of pages	9
Journal	Developmental and Comparative Immunology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.dci.2004.04.003
State	Published - Aug 2004

Bibliographical note

Funding Information:
We are grateful to C. Rabinowitz for technical assistance. Funded by grants from the NIH (ROI-DK54762), the Israel Science Foundation (456/01) and the US–Israel Binational Science Foundation. N.S.-B. was a doctoral fellow of Ch. Clore Foundation. This study is part of N.S.-B. PhD dissertation at Bar-Ilan University.

Funding

We are grateful to C. Rabinowitz for technical assistance. Funded by grants from the NIH (ROI-DK54762), the Israel Science Foundation (456/01) and the US–Israel Binational Science Foundation. N.S.-B. was a doctoral fellow of Ch. Clore Foundation. This study is part of N.S.-B. PhD dissertation at Bar-Ilan University.

Funders	Funder number
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK054762
United States-Israel Binational Science Foundation
Israel Science Foundation	456/01

Keywords

Autoimmunity
Botryllus
Chimerism
DES, double-edged sword
Stem cells

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10.1016/j.dci.2004.04.003

Cite this

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title = "Protochordate concordant xenotransplantation settings reveal outbreaks of donor cells and divergent life span traits",

abstract = "If fulminate rejection in allogeneic and xenogeneic engraftments is not an evolutionary relict feature, then any treatment that ablates the host surveillance's effector arms capabilities and eliminates graft vs. host reactivity should induce donor chimerism in transplant settings. We demonstrate here marked proliferative response of Botryllus (Urochordata) blood cells months following their infusions (2×104-105 blood cells per host) into the concordant xenogeneic environment of irradiated Botrylloides soma. The state of infused cells was followed by Botryllus specific microsatellite alleles on DNA samples from host zooids and vascular system. Increased growth rates and life spans of engrafted hosts in some cases, and sudden chimerical death following the outbreak of donor cells in others, indicate a 'double-edged sword' expression of concurrent evolutionary selected mechanisms. This DES phenomenon in immunity underlies divergent stem cell competition phenomena in multicellular organisms, leading in mammals, to cases of autoimmune diseases vis-{\`a}-vis long-lasting microchimerism events following an iatrogenic transplantation.",

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Protochordate concordant xenotransplantation settings reveal outbreaks of donor cells and divergent life span traits

Abstract

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Keywords

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