Protein Microgels from Amyloid Fibril Networks

Lianne W.Y. Roode, Ulyana Shimanovich, Si Wu, Sarah Perrett, Tuomas P.J. Knowles

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations

Abstract

Nanofibrillar forms of amyloidogenic proteins were initially discovered in the context of protein misfolding and disease but have more recently been found at the origin of key biological functionality in many naturally occurring functional materials, such as adhesives and biofilm coatings. Their physiological roles in nature reflect their great strength and stability, which has led to the exploration of their use as the basis of artificial protein-based functional materials. Particularly for biomedical applications, they represent attractive building blocks for the development of, for instance, drug carrier agents due to their inherent biocompatibility and biodegradability. Furthermore, the propensity of proteins to self-assemble into amyloid fibrils can be exploited under microconfinement, afforded by droplet microfluidic techniques. This approach allows the generation of multi-scale functional microgels that can host biological additives and can be designed to incorporate additional functionality, such as to aid targeted drug delivery.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages223-263
Number of pages41
StatePublished - 2019
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1174
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© 2019, Springer Nature Singapore Pte Ltd.

Keywords

  • Droplet microfluidics
  • Drug carrier agents
  • Functional materials
  • Protein microgels
  • Self-assembled amyloid fibrils

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