Protein kinase C and mammalian spermatozoa acrosome reaction

Zvi Naor, Haim Breitbart

    Research output: Contribution to journalShort surveypeer-review

    33 Scopus citations


    The presence of protein kinase C (PKC) in mammalian sperm was demonstrated by enzymatic activity assay and immunohistochemistry at the light and electron microscopy levels. The sperm head PKC is localized in the acrosome, equatorial segment, and postacrosomal region. In the flagellum, PKC is associated with the segmented column of the neck and is distributed along the mid, principal, and end pieces. Immunoreactive sites are observed in patches along the axoneme and outer dense fibers and are evenly distributed between these regions. Functional studies suggest the involvement of PKC in flagellar motility and acrosome reaction. The cross-talk between the signaling cascades that operate during sperm activation is discussed.

    Original languageEnglish
    Pages (from-to)337-342
    Number of pages6
    JournalTrends in Endocrinology and Metabolism
    Issue number9
    StatePublished - Nov 1997

    Bibliographical note

    Funding Information:
    The active collaboration of R. Rotem, G. Paz, Z. Homonnai, N. Zamir, S. Lazar, M. Tayer, M. Kalina, B. Spungin, Y. Lax, and S. Rubinstein is greatly appreciated. The studies were supported by the Ministry of Health of Israel.


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