Protection against developmental deficiencies by a lipophilic VIP analogue

Illana Gozes, Michal Bachar, Amos Bardea, Ariane Davidson, Sara Rubinraut, Mati Fridkin

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vive using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalNeurochemical Research
Volume23
Issue number5
DOIs
StatePublished - May 1998
Externally publishedYes

Keywords

  • Cholinergic blockade
  • Developmental milestones
  • Hypoxia
  • Learning and memory
  • Vasoactive intestinal peptide

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