Proteasomes crossing the nuclear border

Anca F. Savulescu, Asaf Rotem, Amnon Harel

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Proteasomes localize to different compartments in eukaryotic cells, but the details of this dynamic distribution are poorly understood. Here, we discuss evidence linking pro teasome activity to specific intranuclear locations and the potential mechanisms that may target these large proteolytic machines to the nucleus. Recent work has demonstrated the targeting of intact proteasome particles to newly formed nuclear compartments in a cell-free reconstitution assay.We discuss the difference between open and closed mitosis systems and the targeting of proteasomes to the nuclear periphery, as well as the nucleo plasm. Finally, we present a potential model for regulated assembly of the 26S proteasome holoenzyme inside the nucleus.

Original languageEnglish
Pages (from-to)258-263
Number of pages6
Issue number4
StatePublished - 2011
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants fromthe Israel Science Foundation (813/05 and 1072/10) to A.H.


  • 26S proteasome
  • Nuclear bodies
  • Nuclear import
  • Nuclear pore complex
  • Ran GTPase


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