Prospective evaluation of early follicular ovarian stromal blood flow in infertile women undergoing IVF-ET treatment

Jimmy E. Jadaon, Moshe Ben-Ami, Sami Haddad, Orit Radin, Shalom Bar-Ami, Johnny S. Younis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: To evaluate the role of early follicular stromal flow studies in predicting ovarian response during IVF-ET treatment and to assess their correlation with ovarian reserve parameters and clinical pregnancy achievement. Materials & Methods: One hundred and sixty-eight consecutive and unselected infertile women undergoing their first IVF-ET treatment were included in the study. Basal ovarian reserve and stromal Doppler flow studies were performed in a natural cycle before starting treatment. Four Doppler indices were measured; peak systolic velocity (PSV), pulsatility index (PI), resistance index (RI) and systole/diastole ratio (S/D). Following completion of IVF-ET treatment Pearson's correlation analysis was performed to examine the correlation between Doppler indices, ovarian response, basal ovarian reserve parameters and clinical pregnancy achievement. Results: A positive correlation was found between the number of ≥14mm follicles on hCG day and PSV. The number of ≥14mm follicles and retrieved oocytes had a significant negative correlation with RI and S/D ratio. As well, the number of fertilized oocytes had a significant negative correlation with S/D ratio. Absence of a Doppler signal in one or both ovaries was significantly higher in the women with poor response (31%) as compared to women with normal response (16%). In addition, RI correlated positively with basal FSH as well as FSH/LH ratio and negatively with AFC. The S/D ratio had a negative correlation with AFC (p=0.027). A significant positive correlation between PSV, total ovarian volume (p=0.011) and mean ovarian volume (p=0.019) was detected. However, no correlation between all four Doppler indices and age was detected. Moreover, Doppler indices did not differ significantly between conception and non-conception cycles following IVF-ET treatment. Conclusions: Early follicular stromal Doppler signals is correlated with ovarian response as well as basal ovarian reserve parameters, but have no correlation with age neither with clinical pregnancy achievement in infertile women undergoing IVF-ET treatment.

Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalGynecological Endocrinology
Volume28
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Keywords

  • Controlled ovarian hyperstimulation
  • IVF-ET
  • Ovarian Doppler
  • Ovarian reserve studies
  • Ovarian response

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