Propofol and fentanyl act additively for induction of anaesthesia

I. BEN‐SHLOMO; J. FINGER; E. BAR‐AV; A. Z. PERL; A. ETCHIN; M. TVERSKOY

doi:10.1111/j.1365-2044.1993.tb06846.x

Propofol and fentanyl act additively for induction of anaesthesia

I. BEN‐SHLOMO, J. FINGER, E. BAR‐AV, A. Z. PERL, A. ETCHIN, M. TVERSKOY

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The induction dose‐response of propofol was compared with the dose‐response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose‐response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty‐three percent of the ED₅₀ of fentanyl was required in combination with 75% of the ED₅₀ for propofol to achieve the ED₅₀ of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.

Original language	English
Pages (from-to)	111-113
Number of pages	3
Journal	Anaesthesia
Volume	48
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2044.1993.tb06846.x
State	Published - Feb 1993
Externally published	Yes

Keywords

Anaesthetics
Analgesics
fentanyl
intravenous
propofol

Access to Document

10.1111/j.1365-2044.1993.tb06846.x

Cite this

@article{94eee360d08b4638af0e11e8c7629dd4,

title = "Propofol and fentanyl act additively for induction of anaesthesia",

abstract = "The induction dose‐response of propofol was compared with the dose‐response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose‐response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty‐three percent of the ED50 of fentanyl was required in combination with 75% of the ED50 for propofol to achieve the ED50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.",

keywords = "Anaesthetics, Analgesics, fentanyl, intravenous, propofol",

author = "I. BEN‐SHLOMO and J. FINGER and E. BAR‐AV and PERL, {A. Z.} and A. ETCHIN and M. TVERSKOY",

year = "1993",

month = feb,

doi = "10.1111/j.1365-2044.1993.tb06846.x",

language = "אנגלית",

volume = "48",

pages = "111--113",

journal = "Anaesthesia",

issn = "0003-2409",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

TY - JOUR

T1 - Propofol and fentanyl act additively for induction of anaesthesia

AU - BEN‐SHLOMO, I.

AU - FINGER, J.

AU - BAR‐AV, E.

AU - PERL, A. Z.

AU - ETCHIN, A.

AU - TVERSKOY, M.

PY - 1993/2

Y1 - 1993/2

N2 - The induction dose‐response of propofol was compared with the dose‐response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose‐response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty‐three percent of the ED50 of fentanyl was required in combination with 75% of the ED50 for propofol to achieve the ED50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.

AB - The induction dose‐response of propofol was compared with the dose‐response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose‐response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty‐three percent of the ED50 of fentanyl was required in combination with 75% of the ED50 for propofol to achieve the ED50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.

KW - Anaesthetics

KW - Analgesics

KW - fentanyl

KW - intravenous

KW - propofol

UR - http://www.scopus.com/inward/record.url?scp=0027402992&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2044.1993.tb06846.x

DO - 10.1111/j.1365-2044.1993.tb06846.x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 8460755

AN - SCOPUS:0027402992

SN - 0003-2409

VL - 48

SP - 111

EP - 113

JO - Anaesthesia

JF - Anaesthesia

IS - 2

ER -

Propofol and fentanyl act additively for induction of anaesthesia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this