Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Merav A. Ben-David, Benjamin W. Corn, Ella Evron, Hadassah Goldberg, Raphael M. Pfeffer, Roxoliana Abdah-Bortnyak, Dianna Matceyevsky, Yuliana Weinstein, Orit Golan, Miri Sklair-Levy

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalBreast
Volume49
DOIs
StatePublished - Feb 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Authors

Keywords

  • BPE
  • BRCA
  • Breast cancer
  • Prophylactic breast irradiation

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