Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Merav A. Ben-David; Benjamin W. Corn; Ella Evron; Hadassah Goldberg; Raphael M. Pfeffer; Roxoliana Abdah-Bortnyak; Dianna Matceyevsky; Yuliana Weinstein; Orit Golan; Miri Sklair-Levy

doi:10.1016/j.breast.2019.10.011

Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Merav A. Ben-David, Benjamin W. Corn, Ella Evron, Hadassah Goldberg, Raphael M. Pfeffer, Roxoliana Abdah-Bortnyak, Dianna Matceyevsky, Yuliana Weinstein, Orit Golan, Miri Sklair-Levy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Breast
Volume	49
DOIs	https://doi.org/10.1016/j.breast.2019.10.011
State	Published - Feb 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Authors

Funding

This work was supported by the Israel Cancer Association, grant No. C-20190082.

Funders	Funder number
Israel Cancer Association	C-20190082

Keywords

BPE
BRCA
Breast cancer
Prophylactic breast irradiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.breast.2019.10.011

Cite this

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title = "Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis",

abstract = "Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.",

keywords = "BPE, BRCA, Breast cancer, Prophylactic breast irradiation",

author = "Ben-David, {Merav A.} and Corn, {Benjamin W.} and Ella Evron and Hadassah Goldberg and Pfeffer, {Raphael M.} and Roxoliana Abdah-Bortnyak and Dianna Matceyevsky and Yuliana Weinstein and Orit Golan and Miri Sklair-Levy",

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year = "2020",

month = feb,

doi = "10.1016/j.breast.2019.10.011",

language = "אנגלית",

volume = "49",

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journal = "Breast",

issn = "0960-9776",

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T1 - Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI

T2 - A secondary analysis

AU - Ben-David, Merav A.

AU - Corn, Benjamin W.

AU - Evron, Ella

AU - Goldberg, Hadassah

AU - Pfeffer, Raphael M.

AU - Abdah-Bortnyak, Roxoliana

AU - Matceyevsky, Dianna

AU - Weinstein, Yuliana

AU - Golan, Orit

AU - Sklair-Levy, Miri

PY - 2020/2

Y1 - 2020/2

N2 - Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

AB - Purpose: We recently showed that prophylactic breast irradiation (PBI) reduces the risk of contralateral breast cancer in BRCA mutation carriers undergoing treatment for early breast cancer. It has been suggested that Background Parenchymal Enhancement (BPE) may be a biomarker for increased risk of breast cancer. Methods: For participants in the trial we reviewed the MRI prior to enrollment and following radiation treatment and scored the contralateral breast for BPE and density. Results: Significant reduction of BPE was more commonly noted following PBI (p = 0.011) compared to the control group. Conclusion: Reduction of BPE by PBI may contribute to its prophylactic effect.

KW - BPE

KW - BRCA

KW - Breast cancer

KW - Prophylactic breast irradiation

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Prophylactic breast irradiation reduces background parenchymal enhancement (BPE) on MRI: A secondary analysis

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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