Promotion of neural sprouting using low-level green light-emitting diode phototherapy

Noa Alon, Hamootal Duadi, Ortal Cohen, Tamar Samet, Neta Zilony, Hadas Schori, Orit Shefi, Zeev Zalevsky

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We irradiated neuroblastoma SH-SY5Y cell line with low-level light-emitting diode (LED) illumination at a visible wavelength of 520 nm (green) and intensity of 100 mW/cm2. We captured and analyzed the cell morphology before LED treatment, immediately after, and 12 and 24 h after treatment. Our study demonstrated that LED illumination increases the amount of sprouting dendrites in comparison to the control untreated cells. This treatment also resulted in more elongated cells after treatment in comparison to the control cells and higher levels of expression of a differentiation related gene. This result is a good indication that the proposed method could serve in phototherapy treatment for increasing sprouting and enhancing neural network formation.

Original languageEnglish
Article number020502
JournalJournal of Biomedical Optics
Issue number2
StatePublished - 1 Feb 2015

Bibliographical note

Publisher Copyright:
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE).


  • light-emitting diode illumination
  • neural sprouting
  • phototherapy


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