Abstract
Delivery of drugs through oral mucosa enables bypass of the gastrointestinal tract and “first pass“ metabolism in the liver and the gut. Thus, a higher and less variable bioavailability can be obtained. Mechanisms of this administration route for cannabidiol were investigated in the current research in pigs. Results show that cannabidiol has substantially low permeability rate over 8 h through oral mucosa and accumulates significantly within it. Furthermore, following the removal of the delivery device, residual prolongation of release from the oral mucosa into systemic blood circulation continues for several hours. This method of delivery enabled acquisition of clinically relevant plasma levels of cannabidiol. The absorption profile indicates that cannabidiol, as well as other lipophilic molecules, should be delivered through oral mucosa for systemic absorption from a device that conceals the drug and prevents its washout by the saliva flow and subsequent ingestion into gastrointestinal tract.
| Original language | English |
|---|---|
| Article number | 119276 |
| Journal | International Journal of Pharmaceutics |
| Volume | 581 |
| DOIs | |
| State | Published - 15 May 2020 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2020 Elsevier B.V.
Funding
We wish to highly acknowledge the willingness and hospitality of Dr. Joseph A Nicolazzo from the Monash University, Melbourne, Australia to host Constantin Itin in his laboratory for an internship period, and his and Dr. Liang Jin’s skillful guidance and training in isolation of buccal mucosa and conduction of ex vivo experiments in Ussing diffusion chambers. The traveling expenses of this internship were financially supported by a grant from “The Batsheva de Rothschild Fund for The Advancement of Science in Israel”, for which it is gratefully acknowledged. We wish to highly acknowledge the willingness and hospitality of Dr. Joseph A Nicolazzo from the Monash University, Melbourne, Australia to host Constantin Itin in his laboratory for an internship period, and his and Dr. Liang Jin's skillful guidance and training in isolation of buccal mucosa and conduction of ex vivo experiments in Ussing diffusion chambers. The traveling expenses of this internship were financially supported by a grant from ?The Batsheva de Rothschild Fund for The Advancement of Science in Israel?, for which it is gratefully acknowledged. A. Hoffman and A. Domb are affiliated with the David R. Bloom center for pharmacy at The Hebrew University and the Multidisciplinary Center on Cannabinoid Research.
| Funders |
|---|
| Batsheva de Rothschild Fund |
| Batsheva de Rothschild Fund for The Advancement of Science in Israel? |
| Monash University |
| Hebrew University of Jerusalem |
Keywords
- Buccal
- Cannabidiol
- Cannabinoid
- Drug delivery
- Permeability
- Pharmacokinetics
- Ussing diffusion chamber