Progress and emerging strategies to preserve function in the treatment of sinonasal cancer

Kevin T. Robbins, Ohad Ronen, Nabil F. Saba, Primoz Strojan, Vincent Vander Poorten, Antti Mäkitie, Fernando López, Juan P. Rodrigo, Akihiro Homma, Ehab Hanna, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The sinonasal structures and their adjacent organs host several functions including vision, olfaction, nasal respiration and filtration, secretory immunity, facial expression, articulation, and oral deglutition. We reviewed the current evidence supporting functional preservation in sinonasal cancer treatment. Primary surgery with or without adjuvant modalities continues to be the standard of care for sinonasal cancer. Unfortunately, functional compromise remains a dominant negative feature of this approach. More recently, through advances in therapeutic techniques and improved understanding of the relevant tumor biology, treatments aimed at preserving function and cosmesis are emerging. The evidence for such progress involving minimal access surgery, surgical reconstruction for rehabilitation, new techniques in radiation therapy, inclusion of systemic and locally enhanced chemotherapy, and therapeutic agents based on molecular targets are highlighted. This multi-prong approach bodes well for future patients with sinonasal cancer to undergo successful treatment that includes maximal preservation of associated functions.

Original languageEnglish
Pages (from-to)2955-2966
Number of pages12
JournalHead and Neck
Issue number11
Early online date22 Sep 2023
StatePublished - Nov 2023

Bibliographical note

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  • chemotherapy
  • radiotherapy
  • sinonasal cancer
  • surgery
  • treatment


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