Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

A. Hendricks, F. Gieseler, S. Nazzal, J. H. Bräsen, R. Lucius, B. Sipos, J. H. Claasen, Th Becker, S. Hinz, G. Burmeister, C. Schafmayer, C. Schrader

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies. In terms of colorectal cancer, the impact of proliferation associated proteins is controversially debated. The aim of our study was to examine the expression of topoisomerase II α and minichromosome maintenance protein 6 and to correlate these findings with the clinical data. Methods: Tissue samples of 619 patients in total were stained using the antibodies Ki-S4 and Ki-MCM6 targeting topoisomerase II α as well as minichromosome maintenance protein 6. The median rate of proliferation was correlated with clinical and follow up data. Results: The expression rate of minichromosome maintenance protein 6 is significantly higher than the proportion of topoisomerase II α in tumour cells (p < 0.001). A high expression of both proteins coincides with a beneficial outcome for the patient, indicating a favourable prognostic marker (p < 0.001 and p = 0.008). Conclusions: We have demonstrated that high expression rates of proliferative markers is linked to a beneficial patient outcome. According to the general opinion, a high expression rate correlates with a poor patient outcome. In this study, we were able to refute this assertion.

Original languageEnglish
Article number429
JournalBMC Cancer
Volume19
Issue number1
DOIs
StatePublished - 9 May 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s).

Keywords

  • Colorectal cancer
  • Minichromosome maintenance protein 6
  • Prognostic marker
  • Proliferative proteins
  • Topoisomerase II α

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