Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy

Meital Nuriel-Ohayon; Hadar Neuman; Oren Ziv; Anna Belogolovski; Yiftah Barsheshet; Naamah Bloch; Atara Uzan; Roey Lahav; Avi Peretz; Sigal Frishman; Moshe Hod; Eran Hadar; Yoram Louzoun; Orly Avni; Omry Koren

doi:10.1016/j.celrep.2019.03.075

Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy

Meital Nuriel-Ohayon
, Hadar Neuman
, Oren Ziv
, Anna Belogolovski
, Yiftah Barsheshet
, Naamah Bloch
, Atara Uzan
, Roey Lahav
, Avi Peretz
, Sigal Frishman
, Moshe Hod
, Eran Hadar
, Yoram Louzoun
, Orly Avni
, Omry Koren

Zefat Academic College
Bar-Ilan University
Poriya Medical Center
Tel Aviv University

Research output: Contribution to journal › Article › peer-review

200 Scopus citations

Abstract

Nuriel-Ohayon et al. demonstrate a dramatic shift in the gut microbial composition of women and mice during late pregnancy, including an increase in the relative abundance of Bifidobacterium. Using in vitro and in vivo experiments, they show that supplementation of progesterone affects the microbial communities, including increasing the relative abundance of Bifidobacterium.

Original language	English
Pages (from-to)	730-736.e3
Journal	Cell Reports
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.03.075
State	Published - 16 Apr 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

Funding

O.K. is supported by the Alon fellowship, the Carasso fellowship, and grants funded by IBM , the Marie Curie International Reintegration Grant ( FP7-PEOPLE-2013-CIG-630956 ), the Israel Science Foundation ( 1001/16 ), the Minerva Foundation , the Israeli Ministry of Health ( 3-0000-10451 ), and the Canadian-Israel Health Initiative , jointly funded by the Canadian Institutes of Health Research , the Israel Science Foundation , the International Development Research Centre , Canada, and the Azrieli Foundation ( 2459/15 ). H.N. is supported by the Israeli Ministry of Science Eshkol scholarship ( 3-11714 ).

Funders	Funder number
Canadian-Israel Health Initiative
Israeli Ministry of Science Eshkol scholarship	3-11714
International Business Machines Corporation	FP7-PEOPLE-2013-CIG-630956
Canadian Institutes of Health Research
International Development Research Centre
Minerva Foundation
Israel Science Foundation	1001/16
Azrieli Foundation	2459/15
Ministry of Health, State of Israel	3-0000-10451

Keywords

16S rRNA
Bifidobacterium
gut microbiota
microbiome
pregnancy
progesterone

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10.1016/j.celrep.2019.03.075

Cite this

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abstract = "Nuriel-Ohayon et al. demonstrate a dramatic shift in the gut microbial composition of women and mice during late pregnancy, including an increase in the relative abundance of Bifidobacterium. Using in vitro and in vivo experiments, they show that supplementation of progesterone affects the microbial communities, including increasing the relative abundance of Bifidobacterium.",

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AU - Barsheshet, Yiftah

AU - Bloch, Naamah

AU - Uzan, Atara

AU - Lahav, Roey

AU - Peretz, Avi

AU - Frishman, Sigal

AU - Hod, Moshe

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Progesterone Increases Bifidobacterium Relative Abundance during Late Pregnancy

Abstract

Bibliographical note

Funding

Keywords

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