Pro-angiogenic properties of europium(III) hydroxide nanorods

Chitta Ranjan Patra; Resham Bhattacharya; Sujata Patra; Nicholas E. Vlahakis; Alexandra Gabashvili; Yuri Koltypin; Aharon Gedanken; Priyabrata Mukherjee; Debabrata Mukhopadhyay

doi:10.1002/adma.200701611

Pro-angiogenic properties of europium(III) hydroxide nanorods

Chitta Ranjan Patra
, Resham Bhattacharya
, Sujata Patra
, Nicholas E. Vlahakis
, Alexandra Gabashvili
, Yuri Koltypin
, Aharon Gedanken
, Priyabrata Mukherjee
, Debabrata Mukhopadhyay

Department of Chemistry

Mayo Clinic College of Medicine and Science
Mayo Clinic Rochester, MN
Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [Eu^III(OH)₃] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu ^III(OH)₃] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.

Original language	English
Pages (from-to)	753-756
Number of pages	4
Journal	Advanced Materials
Volume	20
Issue number	4
DOIs	https://doi.org/10.1002/adma.200701611
State	Published - 18 Feb 2008

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title = "Pro-angiogenic properties of europium(III) hydroxide nanorods",

abstract = "A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.",

author = "Patra, \{Chitta Ranjan\} and Resham Bhattacharya and Sujata Patra and Vlahakis, \{Nicholas E.\} and Alexandra Gabashvili and Yuri Koltypin and Aharon Gedanken and Priyabrata Mukherjee and Debabrata Mukhopadhyay",

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doi = "10.1002/adma.200701611",

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AU - Patra, Chitta Ranjan

AU - Bhattacharya, Resham

AU - Patra, Sujata

AU - Vlahakis, Nicholas E.

AU - Gabashvili, Alexandra

AU - Koltypin, Yuri

AU - Gedanken, Aharon

AU - Mukherjee, Priyabrata

AU - Mukhopadhyay, Debabrata

PY - 2008/2/18

Y1 - 2008/2/18

N2 - A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.

AB - A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.

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Pro-angiogenic properties of europium(III) hydroxide nanorods

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