Pro-angiogenic properties of europium(III) hydroxide nanorods

Chitta Ranjan Patra, Resham Bhattacharya, Sujata Patra, Nicholas E. Vlahakis, Alexandra Gabashvili, Yuri Koltypin, Aharon Gedanken, Priyabrata Mukherjee, Debabrata Mukhopadhyay

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99 Scopus citations

Abstract

A study was conducted to observe the unique pro-angiogenic properties of europium (III) hydroxide [EuIII(OH)3] nanorods, synthesized by a microwave technique, to understand the biological impact of lanthanide elements. These nanorods promote endothelial cell proliferation in vitro and vascular sprouting in vivo. Generation of ROS and activation of MAPK induced by these nanorods might be the plausible mechanism for angiogenesis. A detailed mechanistic study and in vivo experiments are in progress to elucidate more detailed physico-chemical and biological activities of these nanorods, as exploration continues in this research field in angiogenesis using inorganic compounds, with not a single report of an angiogenesis using inorganic nanoparticles. The new pro-angiogenic properties of inorganic [Eu III(OH)3] nanorods may also be used to develop new treatment treatment strategies for cardiovascular inchemic and limb ischemia-related diseases in future.

Original languageEnglish
Pages (from-to)753-756
Number of pages4
JournalAdvanced Materials
Volume20
Issue number4
DOIs
StatePublished - 18 Feb 2008

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