Prevalence of early and late prematurity is similar among pediatric type 1 diabetes patients and the general population

Adi Adar, Shlomit Shalitin, Ori Eyal, Neta Loewenthal, Orit Pinhas-Hamiel, Milana Levy, Orna Dally-Gottfried, Zohar Landau, Amnon Zung, Floris Levy-Khademi, David Zangen, Yardena Tenenbaum-Rakover, Marianna Rachmiel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: The incidence of type 1 diabetes mellitus (T1DM) has increased in recent decades, as has the incidence of preterm births (<37 weeks). We aimed to evaluate and compare the prevalence of prematurity and early prematurity (<34 weeks) and birth season variability among T1DM and non-T1DM children. Methods: A nationwide cross-sectional study was conducted, with linkage of data from 13 paediatric diabetes centers and Israeli National Registries, including T1DM patients and general non-T1DM population, born during 2000 to 2013. Gathered data included ethnicity, gender, birth week, weight, and season. The prevalence of prematurity and birth season were compared with the general population birth registry using Pearson Chi-square test. Results: The study population included 1452 T1DM patients, 52.7% males, and 2 138 668 subjects in the general non-T1DM population, 51.2% males. The prevalence of late and early prematurity was similar between groups (6.1% and 2.2% in the T1DM group vs 5.6% and 2.0% in the general non-T1DM group, P = 0.25 and P = 0.38, respectively). OR for prematurity among T1DM patients was 1.15 (0.95-1.39), P = 0.16. No difference in birth season was demonstrated between preterm and term, in T1DM and general non-T1DM populations. Ethiopian descent was more prevalent among T1DM patients compared with the non-T1DM population, in both term and preterm born. Conclusions: This is the largest population-based study, and the first in the Middle East geographical area, indicating that prematurity, including early prematurity, is not associated with T1DM during childhood. The study was registered at NCT02929953.

Original languageEnglish
Article numbere2996
JournalDiabetes/Metabolism Research and Reviews
Issue number5
StatePublished - Jul 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 John Wiley & Sons, Ltd.


We would like to thank Dr Ziv Tomer from the Department of Epidemiology and Preventive Medicine, School of Public Health, Tel Aviv University, for the statistical analysis, and Dr Sara Bar-Yehuda from the Medical Research Unit, Assaf Harofeh Medical Center, for editorial and language assistance. This study was presented as an oral presentation at the annual Israel Society for Clinical Paediatrics meeting in February 2016, as a poster presentation at the International ENDO 2016 meeting in April 2016, and at the European Society of Paediatric Endocrinology meeting in September 2017.

FundersFunder number
Department of Epidemiology and Preventive Medicine, School of Public Health
European Society for Paediatric Endocrinology
Tel Aviv University


    • premature birth
    • prevalence
    • registries
    • seasonal variation
    • type 1 diabetes mellitus


    Dive into the research topics of 'Prevalence of early and late prematurity is similar among pediatric type 1 diabetes patients and the general population'. Together they form a unique fingerprint.

    Cite this