Preparation of 2-thiazolines from (1,2)-thioamido-alcohols; DAST as a useful reagent

Pierre Lafargue, Pierre Guenot, Jean Paul Lellouche

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Diethylamidosulfur trifluoride (DAST) is shown to be a valuable reagent for the ready access to 2-thiazolines 4a-f starting from the corresponding (1,2)-thioamido-alcohols 3a-f. This mild intramolecular cyclization is fast (< 1 h) and occurs at a temperature as low as-78 °C.

Original languageEnglish
Pages (from-to)171-172
Number of pages2
Issue number2
StatePublished - Feb 1995
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 1995 Georg Thieme Verlag, Rudigerstr. 14, 70469 Stuttgart, Germany. All rights reserved.


  • 2-Thiazolines
  • DAST


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