TY - JOUR
T1 - Preparation and in vitro characterization of paclitaxel containing poly(lactic acid co-castor oil)-based nanodispersions
AU - Hiremath, J. G.
AU - Rajeshkumar, A.
AU - Ickowicz, D.
AU - Domb, A. J.
PY - 2013
Y1 - 2013
N2 - Paclitaxel-loaded nanosized particles (NPs) of poly(lactic acid co castor oil) 60:40% w/w- (p(DLLA:CO) were prepared by nanoprecipitation method and lyophilized using cryoprotectants. The prepared nanoparticles were evaluated for encapsulation efficiency and drug release. The formulations were also characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and particle size. From the SEM microphotographs, NPs were obtained in the form of long, flat scales which are similar to rod/bone and rose flower-like shaped nanosized drug delivery systems. FTIR, XRD and DSC results proved that the drug is encapsulated in the polymeric matrix in the amorphous state. Formulations obtained were below 400 nm.
AB - Paclitaxel-loaded nanosized particles (NPs) of poly(lactic acid co castor oil) 60:40% w/w- (p(DLLA:CO) were prepared by nanoprecipitation method and lyophilized using cryoprotectants. The prepared nanoparticles were evaluated for encapsulation efficiency and drug release. The formulations were also characterized by Fourier transform infrared (FTIR), powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and particle size. From the SEM microphotographs, NPs were obtained in the form of long, flat scales which are similar to rod/bone and rose flower-like shaped nanosized drug delivery systems. FTIR, XRD and DSC results proved that the drug is encapsulated in the polymeric matrix in the amorphous state. Formulations obtained were below 400 nm.
KW - Drug delivery
KW - Nanoparticles
KW - Poly(lactic acid-co-castor oil)
UR - http://www.scopus.com/inward/record.url?scp=84884882900&partnerID=8YFLogxK
U2 - 10.1016/s1773-2247(13)50063-3
DO - 10.1016/s1773-2247(13)50063-3
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AN - SCOPUS:84884882900
SN - 1773-2247
VL - 23
SP - 439
EP - 444
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
IS - 5
ER -