Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats

Aron Weller; Iris Herman Gispan; Rinat Armony-Sivan; Robert C. Ritter; Gerard P. Smith

doi:10.1016/S0031-9384(97)00256-4

Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats

Aron Weller
, Iris Herman Gispan
, Rinat Armony-Sivan
, Robert C. Ritter
, Gerard P. Smith

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweanling rats. Gastric preloads (5% b.wt.) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake more than preloads of mineral oil, it is probable that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CCK(A) antagonist, significantly reduced the inhibition produced by corn oil.

Original language	English
Pages (from-to)	871-874
Number of pages	4
Journal	Physiology and Behavior
Volume	62
Issue number	4
DOIs	https://doi.org/10.1016/S0031-9384(97)00256-4
State	Published - Oct 1997

Bibliographical note

Funding Information:
We thank Ofra Schwartz for technical assistance and Berkeley Cooley for processing the manuscript. We also thank Drs. J. Davis and T. Houpt for constructive criticism of earlier versions of this paper. This research was supported by the U.S.-Israel Binational Science Foundation. Dr. Smith is supported by a Research Scientist Award (MH00149) from the National Institute of Mental Health and Dr. Ritter is supported by NIH Grant NS-20561.

Funding

We thank Ofra Schwartz for technical assistance and Berkeley Cooley for processing the manuscript. We also thank Drs. J. Davis and T. Houpt for constructive criticism of earlier versions of this paper. This research was supported by the U.S.-Israel Binational Science Foundation. Dr. Smith is supported by a Research Scientist Award (MH00149) from the National Institute of Mental Health and Dr. Ritter is supported by NIH Grant NS-20561.

Funders	Funder number
U.S.-Israel Binational Science Foundation	MH00149
National Institutes of Health
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke	R01NS020561

Keywords

Cholecystokinin
Cholecystokinin antagonists
Ontogeny of food intake
Postingestive negative feedback
Satiating effect of fat

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10.1016/S0031-9384(97)00256-4

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title = "Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats",

abstract = "The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweanling rats. Gastric preloads (5\% b.wt.) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake more than preloads of mineral oil, it is probable that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CCK(A) antagonist, significantly reduced the inhibition produced by corn oil.",

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author = "Aron Weller and Gispan, \{Iris Herman\} and Rinat Armony-Sivan and Ritter, \{Robert C.\} and Smith, \{Gerard P.\}",

note = "Funding Information: We thank Ofra Schwartz for technical assistance and Berkeley Cooley for processing the manuscript. We also thank Drs. J. Davis and T. Houpt for constructive criticism of earlier versions of this paper. This research was supported by the U.S.-Israel Binational Science Foundation. Dr. Smith is supported by a Research Scientist Award (MH00149) from the National Institute of Mental Health and Dr. Ritter is supported by NIH Grant NS-20561.",

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AU - Smith, Gerard P.

N1 - Funding Information: We thank Ofra Schwartz for technical assistance and Berkeley Cooley for processing the manuscript. We also thank Drs. J. Davis and T. Houpt for constructive criticism of earlier versions of this paper. This research was supported by the U.S.-Israel Binational Science Foundation. Dr. Smith is supported by a Research Scientist Award (MH00149) from the National Institute of Mental Health and Dr. Ritter is supported by NIH Grant NS-20561.

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N2 - The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweanling rats. Gastric preloads (5% b.wt.) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake more than preloads of mineral oil, it is probable that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CCK(A) antagonist, significantly reduced the inhibition produced by corn oil.

AB - The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweanling rats. Gastric preloads (5% b.wt.) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake more than preloads of mineral oil, it is probable that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CCK(A) antagonist, significantly reduced the inhibition produced by corn oil.

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KW - Satiating effect of fat

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Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats

Abstract

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Keywords

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