Preloads of corn oil inhibit independent ingestion on postnatal day 15 in rats

Aron Weller, Iris Herman Gispan, Rinat Armony-Sivan, Robert C. Ritter, Gerard P. Smith

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21 Scopus citations


The ontogenetic development of postingestive inhibitory control of ingestion by an oil preload was examined in preweanling rats. Gastric preloads (5% b.wt.) of water, mineral oil or corn oil were administered 5 min before a 30-min intake test in which pups licked milk from the floor of a test chamber. Preloads of corn oil decreased intake significantly compared with preloads of mineral oil or water on Postnatal Days 15 and 18, but not on Postnatal Day 12. Because preloads of corn oil reduced intake more than preloads of mineral oil, it is probable that the inhibitory effect of corn oil is due to its fats rather than to its oily texture. Cholecystokinin (CCK), presumably released from the small intestine, apparently mediates part of this inhibitory effect because pretreatment with devazepide, a specific CCK(A) antagonist, significantly reduced the inhibition produced by corn oil.

Original languageEnglish
Pages (from-to)871-874
Number of pages4
JournalPhysiology and Behavior
Issue number4
StatePublished - Oct 1997

Bibliographical note

Funding Information:
We thank Ofra Schwartz for technical assistance and Berkeley Cooley for processing the manuscript. We also thank Drs. J. Davis and T. Houpt for constructive criticism of earlier versions of this paper. This research was supported by the U.S.-Israel Binational Science Foundation. Dr. Smith is supported by a Research Scientist Award (MH00149) from the National Institute of Mental Health and Dr. Ritter is supported by NIH Grant NS-20561.


  • Cholecystokinin
  • Cholecystokinin antagonists
  • Ontogeny of food intake
  • Postingestive negative feedback
  • Satiating effect of fat


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