Predictors of coverage of the national maternal pertussis and infant rotavirus vaccination programmes in England

L. Byrne, C. Ward, J. M. White, G. Amirthalingam, M. Edelstein

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


This study assessed variation in coverage of maternal pertussis vaccination, introduced in England in October 2012 in response to a national outbreak, and a new infant rotavirus vaccination programme, implemented in July 2013. Vaccine eligible patients were included from national vaccine coverage datasets and covered April 2014 to March 2015 for pertussis and January 2014 to June 2016 for rotavirus. Vaccine coverage (%) was calculated overall and by NHS England Local Team (LT), ethnicity and Index of Multiple Deprivation (IMD) quintile, and compared using binomial regression. Compared with white-British infants, the largest differences in rotavirus coverage were in 'other', white-Irish and black-Caribbean infants (-13·9%,-12·1% and-10·7%, respectively), after adjusting for IMD and LT. The largest differences in maternal pertussis coverage were in black-other and black-Caribbean women (-16·3% and-15·4%, respectively). Coverage was lowest in London LT for both programmes. Coverage decreased with increasing deprivation and was 14·0% lower in the most deprived quintile compared with the least deprived for the pertussis programme and 4·4% lower for rotavirus. Patients' ethnicity and deprivation were therefore predictors of coverage which contributed to, but did not wholly account for, geographical variation in coverage in England.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalEpidemiology and Infection
Issue number2
StatePublished - 1 Jan 2018
Externally publishedYes

Bibliographical note

Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors would like to acknowledge all staff in PHE and NHS England responsible for the planning and delivery of the maternal pertussis and infant rotavirus immunisation programmes. The authors thank the ImmForm team for their management of the GP sentinel data collections and Vanessa Saliba and Karen Tiley for their work on vaccine coverage and collection of ethnicity data.

Publisher Copyright:
© 2017 Cambridge University Press .


  • Ethnicity
  • inequalities
  • vaccination


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