Prediction of the deficit syndrome from initial deficit symptoms in the early course of schizophrenia

Kenneth L. Subotnik; Keith H. Nuechterlein; Joseph Ventura; Michael F. Green; Sun S. Hwang

doi:10.1016/s0165-1781(98)00052-3

Prediction of the deficit syndrome from initial deficit symptoms in the early course of schizophrenia

Kenneth L. Subotnik
, Keith H. Nuechterlein
, Joseph Ventura
, Michael F. Green
, Sun S. Hwang

University of California at Los Angeles

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The Proxy for the Deficit Syndrome (PDS) was used with longitudinal symptom assessment data to identify recent-onset schizophrenia patients with the deficit syndrome. We evaluated the stability of deficit symptoms using repeated assessments. Symptom ratings were examined at an initial point of outpatient stabilization on antipsychotic medication as well as prospectively over the subsequent 12 months of outpatient treatment and assessment in 83 recent-onset schizophrenia patients. The vast majority of patients who were classified as non-deficit at the cross-sectional baseline assessment continued to remain non-deficit throughout the first year of treatment. However, patients classified as deficit at baseline did not consistently remain classified as showing deficit syndrome during the follow-through period. Thus, the presence of deficit symptoms detected in a single cross- sectional rating may be an inaccurate way to rate the deficit syndrome, yielding excessive false positives. Our use of longitudinal data allowed the stability criterion of the deficit syndrome to be evaluated using the PDS.

Original language	English
Pages (from-to)	53-59
Number of pages	7
Journal	Psychiatry Research
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/s0165-1781(98)00052-3
State	Published - 27 Jul 1998
Externally published	Yes

Bibliographical note

Funding Information:
We thank the UCLA Aftercare Research Program patients who participated in the research and who are contributing to a better understanding of their illnesses. We also gratefully acknowledge consultation from Jim Mintz, Ph.D., Chief of the Methodology and Statistical Support Unit of the UCLA Intervention Research Center for Major Mental Illnesses (directed by Robert P. Liberman, M.D.). We thank the clinicians and staff who helped in the collection and recording of the symptom information: Craig Childress, M.A., Sally Friedlob, M.S.W., Debbie Gioia-Hasick, M.S.W., Portia Loughman, B.A., David Lukoff, Ph.D., Mark McGee, B.A., Sandra Rappe, M.S.W., Mitchell Stoddard, Ph.D., Margie Stratton, M.S.W., and Joseph Tietz, Ph.D. We also thank Michael Gitlin, M.D., David Fogelson, M.D., and George Bartzokis, M.D., for supervision of the medication and psychiatric care of the Aftercare Program patients. We thank Brian Kirkpatrick, M.D., of the Maryland Psychiatric Research Center for his valuable consultation regarding the use of the Proxy for Deficit Syndrome. This research was supported in part by National Institute of Mental Health research grants MH37705 and MH30911.

Funding

We thank the UCLA Aftercare Research Program patients who participated in the research and who are contributing to a better understanding of their illnesses. We also gratefully acknowledge consultation from Jim Mintz, Ph.D., Chief of the Methodology and Statistical Support Unit of the UCLA Intervention Research Center for Major Mental Illnesses (directed by Robert P. Liberman, M.D.). We thank the clinicians and staff who helped in the collection and recording of the symptom information: Craig Childress, M.A., Sally Friedlob, M.S.W., Debbie Gioia-Hasick, M.S.W., Portia Loughman, B.A., David Lukoff, Ph.D., Mark McGee, B.A., Sandra Rappe, M.S.W., Mitchell Stoddard, Ph.D., Margie Stratton, M.S.W., and Joseph Tietz, Ph.D. We also thank Michael Gitlin, M.D., David Fogelson, M.D., and George Bartzokis, M.D., for supervision of the medication and psychiatric care of the Aftercare Program patients. We thank Brian Kirkpatrick, M.D., of the Maryland Psychiatric Research Center for his valuable consultation regarding the use of the Proxy for Deficit Syndrome. This research was supported in part by National Institute of Mental Health research grants MH37705 and MH30911.

Funders	Funder number
National Institute of Mental Health	P30MH030911, MH37705

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

First episode
Longitudinal assessment
Negative symptoms
Proxy for the Deficit Syndrome
Schizophrenia
Withdrawal- retardation

Access to Document

10.1016/s0165-1781(98)00052-3

Cite this

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title = "Prediction of the deficit syndrome from initial deficit symptoms in the early course of schizophrenia",

abstract = "The Proxy for the Deficit Syndrome (PDS) was used with longitudinal symptom assessment data to identify recent-onset schizophrenia patients with the deficit syndrome. We evaluated the stability of deficit symptoms using repeated assessments. Symptom ratings were examined at an initial point of outpatient stabilization on antipsychotic medication as well as prospectively over the subsequent 12 months of outpatient treatment and assessment in 83 recent-onset schizophrenia patients. The vast majority of patients who were classified as non-deficit at the cross-sectional baseline assessment continued to remain non-deficit throughout the first year of treatment. However, patients classified as deficit at baseline did not consistently remain classified as showing deficit syndrome during the follow-through period. Thus, the presence of deficit symptoms detected in a single cross- sectional rating may be an inaccurate way to rate the deficit syndrome, yielding excessive false positives. Our use of longitudinal data allowed the stability criterion of the deficit syndrome to be evaluated using the PDS.",

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author = "Subotnik, \{Kenneth L.\} and Nuechterlein, \{Keith H.\} and Joseph Ventura and Green, \{Michael F.\} and Hwang, \{Sun S.\}",

note = "Funding Information: We thank the UCLA Aftercare Research Program patients who participated in the research and who are contributing to a better understanding of their illnesses. We also gratefully acknowledge consultation from Jim Mintz, Ph.D., Chief of the Methodology and Statistical Support Unit of the UCLA Intervention Research Center for Major Mental Illnesses (directed by Robert P. Liberman, M.D.). We thank the clinicians and staff who helped in the collection and recording of the symptom information: Craig Childress, M.A., Sally Friedlob, M.S.W., Debbie Gioia-Hasick, M.S.W., Portia Loughman, B.A., David Lukoff, Ph.D., Mark McGee, B.A., Sandra Rappe, M.S.W., Mitchell Stoddard, Ph.D., Margie Stratton, M.S.W., and Joseph Tietz, Ph.D. We also thank Michael Gitlin, M.D., David Fogelson, M.D., and George Bartzokis, M.D., for supervision of the medication and psychiatric care of the Aftercare Program patients. We thank Brian Kirkpatrick, M.D., of the Maryland Psychiatric Research Center for his valuable consultation regarding the use of the Proxy for Deficit Syndrome. This research was supported in part by National Institute of Mental Health research grants MH37705 and MH30911.",

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N2 - The Proxy for the Deficit Syndrome (PDS) was used with longitudinal symptom assessment data to identify recent-onset schizophrenia patients with the deficit syndrome. We evaluated the stability of deficit symptoms using repeated assessments. Symptom ratings were examined at an initial point of outpatient stabilization on antipsychotic medication as well as prospectively over the subsequent 12 months of outpatient treatment and assessment in 83 recent-onset schizophrenia patients. The vast majority of patients who were classified as non-deficit at the cross-sectional baseline assessment continued to remain non-deficit throughout the first year of treatment. However, patients classified as deficit at baseline did not consistently remain classified as showing deficit syndrome during the follow-through period. Thus, the presence of deficit symptoms detected in a single cross- sectional rating may be an inaccurate way to rate the deficit syndrome, yielding excessive false positives. Our use of longitudinal data allowed the stability criterion of the deficit syndrome to be evaluated using the PDS.

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Prediction of the deficit syndrome from initial deficit symptoms in the early course of schizophrenia

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Cite this