Predicting severe motor impairment in preterm children at age 5 years

Anne Synnes; Peter J. Anderson; Ruth E. Grunau; Deborah Dewey; Diane Moddemann; Win Tin; Peter G. Davis; Lex W. Doyle; Gary Foster; May Khairy; Chukwuma Nwaesei; Barbara Schmidt; Judy D'Ilario; Janice Cairnie; Joanne Dix; Beth Anne Adams; Erin Warriner; Mee Hai Marie Kim; Brenda Argus; Catherine Callanan; Noni Davis; Julianne Duff; Marion McDonald; Elizabeth Asztalos; Denise Hohn; Maralyn Lacy; Ross Haslam; Christopher Barnett; Louise Goodchild; Rosslyn Marie Lontis; Simon Fraser; Julie Keng; Kerryn Saunders; Gillian Opie; Elaine Kelly; Heather Woods; Emma Marchant; Anne Marie Turner; Emma Magrath; Amanda Williamson; Aida Bairam; Sylvie Bélanger; Annie Fraser; Marc Blayney; Brigitte Lemyre; Jane Frank; Alfonso Solimano; Philippa Hubber-Richard; Marilyn Rogers; Margot Mackay; Julianne Petrie-Thomas; Arsalan Butt; Aleid Van Wassenaer; Debbie Nuytemans; Bregje Houtzager; Loekie Van Sonderen; Rivka Regev; Netter Itzchack; Shmuel Arnon; Adiba Chalaf; Arne Ohlsson; Karel O'Brien; Anne Marie Hamilton; May Lee Chan; Koravangattu Sankaran; Pat Proctor; Agneta Golan; Esther Goldsch-Lerman; Graham Reynolds; Barbara Dromgool; Andra Meskell; Vanessa Parr; Catherine Maher; Margaret Broom; Zsuzsoka Kecskes; Cathy Ringland; Douglas McMillan; Elizabeth Spellen; Reginald S. Sauve; Heather Christianson; Deborah Anseeuw-Deeks; Dianne Creighton; Jennifer Heath; Ruben Alvaro; Aaron Chiu; Ceceile Porter; Gloria Turner; Naomi Granke; Karen Penner; Jane Bow; Antonius Mulder; Renske Wassenberg; Markus Van Der Hoeven; Maxine Clarke; Judy Parfitt; Kevin Parker; Heather Ryan; Cory Saunders; Andreas Schulze; Inga Wermuth; Anne Hilgendorff; Andreas W. Flemmer; Eric Herlenius; Lena Legnevall; Hugo Lagercrantz; Derek Matthew; Wendy Amos; Suresh Tulsiani; Cherrie Tan-Dy; Marilyn Turner; Constance Phelan; Eric S. Shinwell; Michael Levine; Ada Juster-Reicher; Patricia Grier; Julie Vachon; Larissa Perepolkin; Keith J. Barrington; Sunil Kumar Sinha; Susan Fritz; Herve Walti; Diane Royer; Henry Halliday; David Millar; Clifford Mayes; Christopher McCusker; Olivia McLaughlin; Hubert Fahnenstich; Bettina Tillmann; Peter Weber; Unni Wariyar; Nicholas Embleton; Ravi Swamy; Hans U. Bucher; Jean Claude Fauchere; Vera Dietz; Chidambara Harikumar

doi:10.1136/archdischild-2014-307695

Predicting severe motor impairment in preterm children at age 5 years

Anne Synnes
, Peter J. Anderson
, Ruth E. Grunau
, Deborah Dewey
, Diane Moddemann
, Win Tin
, Peter G. Davis
, Lex W. Doyle
, Gary Foster
, May Khairy
, Chukwuma Nwaesei
, Barbara Schmidt
, Judy D'Ilario
, Janice Cairnie
, Joanne Dix
, Beth Anne Adams
, Erin Warriner
, Mee Hai Marie Kim
, Brenda Argus
, Catherine Callanan

Noni Davis, Julianne Duff, Marion McDonald, Elizabeth Asztalos, Denise Hohn, Maralyn Lacy, Ross Haslam, Christopher Barnett, Louise Goodchild, Rosslyn Marie Lontis, Simon Fraser, Julie Keng, Kerryn Saunders, Gillian Opie, Elaine Kelly, Heather Woods, Emma Marchant, Anne Marie Turner, Emma Magrath, Amanda Williamson, Aida Bairam, Sylvie Bélanger, Annie Fraser, Marc Blayney, Brigitte Lemyre, Jane Frank, Alfonso Solimano, Philippa Hubber-Richard, Marilyn Rogers, Margot Mackay, Julianne Petrie-Thomas, Arsalan Butt, Aleid Van Wassenaer, Debbie Nuytemans, Bregje Houtzager, Loekie Van Sonderen, Rivka Regev, Netter Itzchack, Shmuel Arnon, Adiba Chalaf, Arne Ohlsson, Karel O'Brien, Anne Marie Hamilton, May Lee Chan, Koravangattu Sankaran, Pat Proctor, Agneta Golan, Esther Goldsch-Lerman, Graham Reynolds, Barbara Dromgool, Andra Meskell, Vanessa Parr, Catherine Maher, Margaret Broom, Zsuzsoka Kecskes, Cathy Ringland, Douglas McMillan, Elizabeth Spellen, Reginald S. Sauve, Heather Christianson, Deborah Anseeuw-Deeks, Dianne Creighton, Jennifer Heath, Ruben Alvaro, Aaron Chiu, Ceceile Porter, Gloria Turner, Naomi Granke, Karen Penner, Jane Bow, Antonius Mulder, Renske Wassenberg, Markus Van Der Hoeven, Maxine Clarke, Judy Parfitt, Kevin Parker, Heather Ryan, Cory Saunders, Andreas Schulze, Inga Wermuth, Anne Hilgendorff, Andreas W. Flemmer, Eric Herlenius, Lena Legnevall, Hugo Lagercrantz, Derek Matthew, Wendy Amos, Suresh Tulsiani, Cherrie Tan-Dy, Marilyn Turner, Constance Phelan, Eric S. Shinwell, Michael Levine, Ada Juster-Reicher, Patricia Grier, Julie Vachon, Larissa Perepolkin, Keith J. Barrington, Sunil Kumar Sinha, Susan Fritz, Herve Walti, Diane Royer, Henry Halliday, David Millar, Clifford Mayes, Christopher McCusker, Olivia McLaughlin, Hubert Fahnenstich, Bettina Tillmann, Peter Weber, Unni Wariyar, Nicholas Embleton, Ravi Swamy, Hans U. Bucher, Jean Claude Fauchere, Vera Dietz, Chidambara Harikumar

Department of Pediatrics
University of British Columbia
Children's and Women's Health Centre of BC
Clinical Sciences
Murdoch Children's Research Institute
University of Melbourne
Royal Women's Hospital
Alberta Children's Hospital Research Institute for Child and Maternal Health
University of Calgary
Department of Pediatrics and Child Health
University of Manitoba
St. Boniface
Department of Paediatrics
South Tees Hospitals NHS Foundation Trust
Northern Neonatal Initiatives
Department of Clinical Epidemiology and Biostatistics
McMaster University
McGill University
Windsor Regional Hospital
Division of Neonatology
University of Pennsylvania
McMaster University Medical Center
Mercy Hospital for Women
University of Toronto
Women's and Children's Hospital Adelaide
Centre Hospitalier Universitaire de Quebec
University of Ottawa
Academic Medical Center
Meir Hospital Sapir Medical Center
Saskatchewan Health Authority
Soroka Medical Center
Canberra Hospital
Foothills Medical Centre
Maastricht University
Kingston General Hospital, Ontario
Ludwig Maximilian University of Munich
Karolinska Institutet
Victoria General Hospital
Kaplan Medical Center Israel
Université de Sherbrooke
Belfast Health and Social Care Trust
University of Basel
Newcastle upon Tyne Hospitals NHS Foundation Trust
University of Zurich

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objective To determine whether the ability to predict severe motor impairment at age 5 years improves between birth and 18 months. Design Ancillary study of the Caffeine for Apnea of Prematurity Trial. Setting and Patients International cohort of very low birth weight children who were assessed sequentially from birth to 5 years. Outcome Measures Severe motor impairment was defined as a score <5th percentile on the Movement Assessment Battery of Children (MABC), or inability to complete the MABC because of cerebral palsy. Multivariable logistic regression cumulative risk models used four sets of predictor variables: early neonatal risk factors, risk factors at 36 weeks' postmenstrual age, risk factors at a corrected age of 18 months, and sociodemographic variables. A receiver operating characteristic curve (ROC) was generated for each model, and the four ROC curves were compared to determine if the addition of the new set of predictors significantly increased the area under the curve (AUC). Results Of 1469 children, 291 (19.8%) had a severe motor impairment at 5 years. The AUC increased from 0.650 soon after birth, to 0.718 (p<0.001) at 36 weeks' postmenstrual age, and to 0.797 at 18 months ( p<0.001). Sociodemographic variables did not significantly improve the AUC (AUC=0.806; p=0.07). Conclusions Prediction of severe motor impairment at 5 years of age using a cumulative risk model improves significantly from birth to 18 months of age in children with birth weights between 500 g and 1250 g.

Original language	English
Pages (from-to)	748-753
Number of pages	6
Journal	Archives of Disease in Childhood
Volume	100
Issue number	8
DOIs	https://doi.org/10.1136/archdischild-2014-307695
State	Published - 1 Aug 2015
Externally published	Yes

Funding

Funders	Funder number
Canadian Institutes of Health Research	MCT 13288

Access to Document

10.1136/archdischild-2014-307695

Cite this

Synnes, A., Anderson, P. J., Grunau, R. E., Dewey, D., Moddemann, D., Tin, W., Davis, P. G., Doyle, L. W., Foster, G., Khairy, M., Nwaesei, C., Schmidt, B., D'Ilario, J., Cairnie, J., Dix, J., Adams, B. A., Warriner, E., Kim, M. H. M., Argus, B., ... Harikumar, C. (2015). Predicting severe motor impairment in preterm children at age 5 years. Archives of Disease in Childhood, 100(8), 748-753. https://doi.org/10.1136/archdischild-2014-307695

@article{b75c518bbef3489f9f75763010612afb,

title = "Predicting severe motor impairment in preterm children at age 5 years",

abstract = "Objective To determine whether the ability to predict severe motor impairment at age 5 years improves between birth and 18 months. Design Ancillary study of the Caffeine for Apnea of Prematurity Trial. Setting and Patients International cohort of very low birth weight children who were assessed sequentially from birth to 5 years. Outcome Measures Severe motor impairment was defined as a score <5th percentile on the Movement Assessment Battery of Children (MABC), or inability to complete the MABC because of cerebral palsy. Multivariable logistic regression cumulative risk models used four sets of predictor variables: early neonatal risk factors, risk factors at 36 weeks' postmenstrual age, risk factors at a corrected age of 18 months, and sociodemographic variables. A receiver operating characteristic curve (ROC) was generated for each model, and the four ROC curves were compared to determine if the addition of the new set of predictors significantly increased the area under the curve (AUC). Results Of 1469 children, 291 (19.8\%) had a severe motor impairment at 5 years. The AUC increased from 0.650 soon after birth, to 0.718 (p<0.001) at 36 weeks' postmenstrual age, and to 0.797 at 18 months ( p<0.001). Sociodemographic variables did not significantly improve the AUC (AUC=0.806; p=0.07). Conclusions Prediction of severe motor impairment at 5 years of age using a cumulative risk model improves significantly from birth to 18 months of age in children with birth weights between 500 g and 1250 g.",

author = "Anne Synnes and Anderson, \{Peter J.\} and Grunau, \{Ruth E.\} and Deborah Dewey and Diane Moddemann and Win Tin and Davis, \{Peter G.\} and Doyle, \{Lex W.\} and Gary Foster and May Khairy and Chukwuma Nwaesei and Barbara Schmidt and Judy D'Ilario and Janice Cairnie and Joanne Dix and Adams, \{Beth Anne\} and Erin Warriner and Kim, \{Mee Hai Marie\} and Brenda Argus and Catherine Callanan and Noni Davis and Julianne Duff and Marion McDonald and Elizabeth Asztalos and Denise Hohn and Maralyn Lacy and Ross Haslam and Christopher Barnett and Louise Goodchild and Lontis, \{Rosslyn Marie\} and Simon Fraser and Julie Keng and Kerryn Saunders and Gillian Opie and Elaine Kelly and Heather Woods and Emma Marchant and Turner, \{Anne Marie\} and Emma Magrath and Amanda Williamson and Aida Bairam and Sylvie B{\'e}langer and Annie Fraser and Marc Blayney and Brigitte Lemyre and Jane Frank and Alfonso Solimano and Philippa Hubber-Richard and Marilyn Rogers and Margot Mackay and Julianne Petrie-Thomas and Arsalan Butt and \{Van Wassenaer\}, Aleid and Debbie Nuytemans and Bregje Houtzager and \{Van Sonderen\}, Loekie and Rivka Regev and Netter Itzchack and Shmuel Arnon and Adiba Chalaf and Arne Ohlsson and Karel O'Brien and Hamilton, \{Anne Marie\} and Chan, \{May Lee\} and Koravangattu Sankaran and Pat Proctor and Agneta Golan and Esther Goldsch-Lerman and Graham Reynolds and Barbara Dromgool and Andra Meskell and Vanessa Parr and Catherine Maher and Margaret Broom and Zsuzsoka Kecskes and Cathy Ringland and Douglas McMillan and Elizabeth Spellen and Sauve, \{Reginald S.\} and Heather Christianson and Deborah Anseeuw-Deeks and Dianne Creighton and Jennifer Heath and Ruben Alvaro and Aaron Chiu and Ceceile Porter and Gloria Turner and Naomi Granke and Karen Penner and Jane Bow and Antonius Mulder and Renske Wassenberg and \{Van Der Hoeven\}, Markus and Maxine Clarke and Judy Parfitt and Kevin Parker and Heather Ryan and Cory Saunders and Andreas Schulze and Inga Wermuth and Anne Hilgendorff and Flemmer, \{Andreas W.\} and Eric Herlenius and Lena Legnevall and Hugo Lagercrantz and Derek Matthew and Wendy Amos and Suresh Tulsiani and Cherrie Tan-Dy and Marilyn Turner and Constance Phelan and Shinwell, \{Eric S.\} and Michael Levine and Ada Juster-Reicher and Patricia Grier and Julie Vachon and Larissa Perepolkin and Barrington, \{Keith J.\} and Sinha, \{Sunil Kumar\} and Susan Fritz and Herve Walti and Diane Royer and Henry Halliday and David Millar and Clifford Mayes and Christopher McCusker and Olivia McLaughlin and Hubert Fahnenstich and Bettina Tillmann and Peter Weber and Unni Wariyar and Nicholas Embleton and Ravi Swamy and Bucher, \{Hans U.\} and Fauchere, \{Jean Claude\} and Vera Dietz and Chidambara Harikumar",

year = "2015",

month = aug,

day = "1",

doi = "10.1136/archdischild-2014-307695",

language = "אנגלית",

volume = "100",

pages = "748--753",

journal = "Archives of Disease in Childhood",

issn = "0003-9888",

publisher = "BMJ Publishing Group",

number = "8",

}

Synnes, A, Anderson, PJ, Grunau, RE, Dewey, D, Moddemann, D, Tin, W, Davis, PG, Doyle, LW, Foster, G, Khairy, M, Nwaesei, C, Schmidt, B, D'Ilario, J, Cairnie, J, Dix, J, Adams, BA, Warriner, E, Kim, MHM, Argus, B, Callanan, C, Davis, N, Duff, J, McDonald, M, Asztalos, E, Hohn, D, Lacy, M, Haslam, R, Barnett, C, Goodchild, L, Lontis, RM, Fraser, S, Keng, J, Saunders, K, Opie, G, Kelly, E, Woods, H, Marchant, E, Turner, AM, Magrath, E, Williamson, A, Bairam, A, Bélanger, S, Fraser, A, Blayney, M, Lemyre, B, Frank, J, Solimano, A, Hubber-Richard, P, Rogers, M, Mackay, M, Petrie-Thomas, J, Butt, A, Van Wassenaer, A, Nuytemans, D, Houtzager, B, Van Sonderen, L, Regev, R, Itzchack, N, Arnon, S, Chalaf, A, Ohlsson, A, O'Brien, K, Hamilton, AM, Chan, ML, Sankaran, K, Proctor, P, Golan, A, Goldsch-Lerman, E, Reynolds, G, Dromgool, B, Meskell, A, Parr, V, Maher, C, Broom, M, Kecskes, Z, Ringland, C, McMillan, D, Spellen, E, Sauve, RS, Christianson, H, Anseeuw-Deeks, D, Creighton, D, Heath, J, Alvaro, R, Chiu, A, Porter, C, Turner, G, Granke, N, Penner, K, Bow, J, Mulder, A, Wassenberg, R, Van Der Hoeven, M, Clarke, M, Parfitt, J, Parker, K, Ryan, H, Saunders, C, Schulze, A, Wermuth, I, Hilgendorff, A, Flemmer, AW, Herlenius, E, Legnevall, L, Lagercrantz, H, Matthew, D, Amos, W, Tulsiani, S, Tan-Dy, C, Turner, M, Phelan, C, Shinwell, ES, Levine, M, Juster-Reicher, A, Grier, P, Vachon, J, Perepolkin, L, Barrington, KJ, Sinha, SK, Fritz, S, Walti, H, Royer, D, Halliday, H, Millar, D, Mayes, C, McCusker, C, McLaughlin, O, Fahnenstich, H, Tillmann, B, Weber, P, Wariyar, U, Embleton, N, Swamy, R, Bucher, HU, Fauchere, JC, Dietz, V & Harikumar, C 2015, 'Predicting severe motor impairment in preterm children at age 5 years', Archives of Disease in Childhood, vol. 100, no. 8, pp. 748-753. https://doi.org/10.1136/archdischild-2014-307695

TY - JOUR

T1 - Predicting severe motor impairment in preterm children at age 5 years

AU - Synnes, Anne

AU - Anderson, Peter J.

AU - Grunau, Ruth E.

AU - Dewey, Deborah

AU - Moddemann, Diane

AU - Tin, Win

AU - Davis, Peter G.

AU - Doyle, Lex W.

AU - Foster, Gary

AU - Khairy, May

AU - Nwaesei, Chukwuma

AU - Schmidt, Barbara

AU - D'Ilario, Judy

AU - Cairnie, Janice

AU - Dix, Joanne

AU - Adams, Beth Anne

AU - Warriner, Erin

AU - Kim, Mee Hai Marie

AU - Argus, Brenda

AU - Callanan, Catherine

AU - Davis, Noni

AU - Duff, Julianne

AU - McDonald, Marion

AU - Asztalos, Elizabeth

AU - Hohn, Denise

AU - Lacy, Maralyn

AU - Haslam, Ross

AU - Barnett, Christopher

AU - Goodchild, Louise

AU - Lontis, Rosslyn Marie

AU - Fraser, Simon

AU - Keng, Julie

AU - Saunders, Kerryn

AU - Opie, Gillian

AU - Kelly, Elaine

AU - Woods, Heather

AU - Marchant, Emma

AU - Turner, Anne Marie

AU - Magrath, Emma

AU - Williamson, Amanda

AU - Bairam, Aida

AU - Bélanger, Sylvie

AU - Fraser, Annie

AU - Blayney, Marc

AU - Lemyre, Brigitte

AU - Frank, Jane

AU - Solimano, Alfonso

AU - Hubber-Richard, Philippa

AU - Rogers, Marilyn

AU - Mackay, Margot

AU - Petrie-Thomas, Julianne

AU - Butt, Arsalan

AU - Van Wassenaer, Aleid

AU - Nuytemans, Debbie

AU - Houtzager, Bregje

AU - Van Sonderen, Loekie

AU - Regev, Rivka

AU - Itzchack, Netter

AU - Arnon, Shmuel

AU - Chalaf, Adiba

AU - Ohlsson, Arne

AU - O'Brien, Karel

AU - Hamilton, Anne Marie

AU - Chan, May Lee

AU - Sankaran, Koravangattu

AU - Proctor, Pat

AU - Golan, Agneta

AU - Goldsch-Lerman, Esther

AU - Reynolds, Graham

AU - Dromgool, Barbara

AU - Meskell, Andra

AU - Parr, Vanessa

AU - Maher, Catherine

AU - Broom, Margaret

AU - Kecskes, Zsuzsoka

AU - Ringland, Cathy

AU - McMillan, Douglas

AU - Spellen, Elizabeth

AU - Sauve, Reginald S.

AU - Christianson, Heather

AU - Anseeuw-Deeks, Deborah

AU - Creighton, Dianne

AU - Heath, Jennifer

AU - Alvaro, Ruben

AU - Chiu, Aaron

AU - Porter, Ceceile

AU - Turner, Gloria

AU - Granke, Naomi

AU - Penner, Karen

AU - Bow, Jane

AU - Mulder, Antonius

AU - Wassenberg, Renske

AU - Van Der Hoeven, Markus

AU - Clarke, Maxine

AU - Parfitt, Judy

AU - Parker, Kevin

AU - Ryan, Heather

AU - Saunders, Cory

AU - Schulze, Andreas

AU - Wermuth, Inga

AU - Hilgendorff, Anne

AU - Flemmer, Andreas W.

AU - Herlenius, Eric

AU - Legnevall, Lena

AU - Lagercrantz, Hugo

AU - Matthew, Derek

AU - Amos, Wendy

AU - Tulsiani, Suresh

AU - Tan-Dy, Cherrie

AU - Turner, Marilyn

AU - Phelan, Constance

AU - Shinwell, Eric S.

AU - Levine, Michael

AU - Juster-Reicher, Ada

AU - Grier, Patricia

AU - Vachon, Julie

AU - Perepolkin, Larissa

AU - Barrington, Keith J.

AU - Sinha, Sunil Kumar

AU - Fritz, Susan

AU - Walti, Herve

AU - Royer, Diane

AU - Halliday, Henry

AU - Millar, David

AU - Mayes, Clifford

AU - McCusker, Christopher

AU - McLaughlin, Olivia

AU - Fahnenstich, Hubert

AU - Tillmann, Bettina

AU - Weber, Peter

AU - Wariyar, Unni

AU - Embleton, Nicholas

AU - Swamy, Ravi

AU - Bucher, Hans U.

AU - Fauchere, Jean Claude

AU - Dietz, Vera

AU - Harikumar, Chidambara

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective To determine whether the ability to predict severe motor impairment at age 5 years improves between birth and 18 months. Design Ancillary study of the Caffeine for Apnea of Prematurity Trial. Setting and Patients International cohort of very low birth weight children who were assessed sequentially from birth to 5 years. Outcome Measures Severe motor impairment was defined as a score <5th percentile on the Movement Assessment Battery of Children (MABC), or inability to complete the MABC because of cerebral palsy. Multivariable logistic regression cumulative risk models used four sets of predictor variables: early neonatal risk factors, risk factors at 36 weeks' postmenstrual age, risk factors at a corrected age of 18 months, and sociodemographic variables. A receiver operating characteristic curve (ROC) was generated for each model, and the four ROC curves were compared to determine if the addition of the new set of predictors significantly increased the area under the curve (AUC). Results Of 1469 children, 291 (19.8%) had a severe motor impairment at 5 years. The AUC increased from 0.650 soon after birth, to 0.718 (p<0.001) at 36 weeks' postmenstrual age, and to 0.797 at 18 months ( p<0.001). Sociodemographic variables did not significantly improve the AUC (AUC=0.806; p=0.07). Conclusions Prediction of severe motor impairment at 5 years of age using a cumulative risk model improves significantly from birth to 18 months of age in children with birth weights between 500 g and 1250 g.

AB - Objective To determine whether the ability to predict severe motor impairment at age 5 years improves between birth and 18 months. Design Ancillary study of the Caffeine for Apnea of Prematurity Trial. Setting and Patients International cohort of very low birth weight children who were assessed sequentially from birth to 5 years. Outcome Measures Severe motor impairment was defined as a score <5th percentile on the Movement Assessment Battery of Children (MABC), or inability to complete the MABC because of cerebral palsy. Multivariable logistic regression cumulative risk models used four sets of predictor variables: early neonatal risk factors, risk factors at 36 weeks' postmenstrual age, risk factors at a corrected age of 18 months, and sociodemographic variables. A receiver operating characteristic curve (ROC) was generated for each model, and the four ROC curves were compared to determine if the addition of the new set of predictors significantly increased the area under the curve (AUC). Results Of 1469 children, 291 (19.8%) had a severe motor impairment at 5 years. The AUC increased from 0.650 soon after birth, to 0.718 (p<0.001) at 36 weeks' postmenstrual age, and to 0.797 at 18 months ( p<0.001). Sociodemographic variables did not significantly improve the AUC (AUC=0.806; p=0.07). Conclusions Prediction of severe motor impairment at 5 years of age using a cumulative risk model improves significantly from birth to 18 months of age in children with birth weights between 500 g and 1250 g.

UR - https://www.scopus.com/pages/publications/84937161917

U2 - 10.1136/archdischild-2014-307695

DO - 10.1136/archdischild-2014-307695

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 25784749

AN - SCOPUS:84937161917

SN - 0003-9888

VL - 100

SP - 748

EP - 753

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

IS - 8

ER -

Predicting severe motor impairment in preterm children at age 5 years

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