Potentials of ionic liquids to overcome physical and biological barriers

Elfa Beaven, Raj Kumar, Jeong Man An, Hannia Mendoza, Sabuj Chandra Sutradhar, Wonho Choi, Mahesh Narayan, Yong kyu Lee, Md Nurunnabi

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Over the last decades, ionic liquids (IL) have shown great potential in non-invasive delivery starting from synthetic small molecules to biological large molecules. ILs are emerging as a particular class of drug delivery systems due to their unique physiochemical properties, simple surface modification, and functionalization. These features of IL help achieve specific design principles that are essential for a non-invasive drug delivery system. In this review, we have discussed IL and their applications in non-invasive drug delivery systems. We evaluated state-of-the-art development and advances of IL aiming to mitigate the biological and physical barriers to improve transdermal and oral delivery, summarized in this review. We also provided an overview of the various factors determining the systemic transportation of IL-based formulation. Additionally, we have emphasized how the ILs facilitate the transportation of therapeutic molecules by overcoming biological barriers.

Original languageEnglish
Article number115157
JournalAdvanced Drug Delivery Reviews
StatePublished - Jan 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier B.V.


The authors are thankful for the support funding received from Cancer Prevention Research Institute of Texas (CPRIT) through Texas Regional Excellence in Cancer Award (TREC) under Award No. RP210153, and National Institutes of Health (NIH) under Award No. R03OD032624. The views presented in this review paper are solely the authors’ responsibility and do not represent the views of NIH. Elfa Beaven acknowledges summer fellowship from National Scleroderma Foundation. The graphical abstract was created using Biorender.com. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2021R1A2C2095113 and 2021R1A6A1A03046418 ).

FundersFunder number
Texas Regional Excellence in Cancer AwardRP210153
National Institutes of HealthR03OD032624
Scleroderma Foundation
Cancer Prevention and Research Institute of Texas
Ministry of Education2021R1A6A1A03046418, NRF-2021R1A2C2095113
National Research Foundation of Korea


    • Biological barrier
    • Ionic liquid
    • Local delivery
    • Noninvasive delivery
    • Systemic delivery


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