Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Patrizia Barozzi; Mario Luppi; Fabio Faccheti; Cristina Mecucci; Milena Alù; Ronit Sarid; Valeria Rasini; Luisa Ravazzini; Elisa Rossi; Silvana Festa; Barbara Crescenzi; Dana G. Wolf; Thomas F. Schulz; Giuseppe Torelli

doi:10.1038/nm862

Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Patrizia Barozzi, Mario Luppi, Fabio Faccheti, Cristina Mecucci, Milena Alù, Ronit Sarid, Valeria Rasini, Luisa Ravazzini, Elisa Rossi, Silvana Festa, Barbara Crescenzi, Dana G. Wolf, Thomas F. Schulz, Giuseppe Torelli

The Mina and Everard Goodman Faculty of Life Sciences

Research output: Contribution to journal › Article › peer-review

196 Scopus citations

Abstract

Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

Original language	English
Pages (from-to)	554-561
Number of pages	8
Journal	Nature Medicine
Volume	9
Issue number	5
DOIs	https://doi.org/10.1038/nm862
State	Published - 1 May 2003

Bibliographical note

Funding Information:
Acknowledgments This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies

Funding

Acknowledgments This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies

Funders	Funder number
Associazione Italiana per la Ricerca sul Cancro

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10.1038/nm862

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title = "Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors",

abstract = "Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.",

author = "Patrizia Barozzi and Mario Luppi and Fabio Faccheti and Cristina Mecucci and Milena Al{\`u} and Ronit Sarid and Valeria Rasini and Luisa Ravazzini and Elisa Rossi and Silvana Festa and Barbara Crescenzi and Wolf, {Dana G.} and Schulz, {Thomas F.} and Giuseppe Torelli",

note = "Funding Information: Acknowledgments This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies",

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AU - Barozzi, Patrizia

AU - Luppi, Mario

AU - Faccheti, Fabio

AU - Mecucci, Cristina

AU - Alù, Milena

AU - Sarid, Ronit

AU - Rasini, Valeria

AU - Ravazzini, Luisa

AU - Rossi, Elisa

AU - Festa, Silvana

AU - Crescenzi, Barbara

AU - Wolf, Dana G.

AU - Schulz, Thomas F.

AU - Torelli, Giuseppe

N1 - Funding Information: Acknowledgments This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

AB - Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

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Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Abstract

Bibliographical note

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