Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

Patrizia Barozzi, Mario Luppi, Fabio Faccheti, Cristina Mecucci, Milena Alù, Ronit Sarid, Valeria Rasini, Luisa Ravazzini, Elisa Rossi, Silvana Festa, Barbara Crescenzi, Dana G. Wolf, Thomas F. Schulz, Giuseppe Torelli

Research output: Contribution to journalArticlepeer-review

194 Scopus citations

Abstract

Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

Original languageEnglish
Pages (from-to)554-561
Number of pages8
JournalNature Medicine
Volume9
Issue number5
DOIs
StatePublished - 1 May 2003

Bibliographical note

Funding Information:
Acknowledgments This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies

Funding

Acknowledgments This study was supported by the Associazione Italiana per la Ricerca sul Cancro, Milan, Italy (M.L.). We thank G. Santagostino, R. Ricci, L. Bignardi, F. Cardarelli, A. Savazzi, G. Pizov and D. Rubinger for providing the KS biopsies

FundersFunder number
Associazione Italiana per la Ricerca sul Cancro

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