Possible serotonergic mediation of induction of sleep signs by dsip and by d-amphetamine

Shlomo Yehuda, David I. Mostofsky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Although the peripheral administration of DSIP (delta sleep inducing peptide) to intact animals does not consistently induce behavioral sleep, potentiation of the effect by d-amphetamine has been established earlier. This study investigated DSIP effects in rats following pretreatment with a MPT and/or 1-tryptophan at various dose levels. A clear potentiation was found. Furthermore, pretreatment with methysergide blocked the emergence of sleep signs in various treated groups. It is proposed that the action of DSIP is best understood in the context of mediation via serotonergic mechanisms.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalInternational Journal of Neuroscience
Issue number3-4
StatePublished - 1982

Bibliographical note

Funding Information:
D. I. Mostofsky, a visiting professor on Sabbatical leave from Boston University (I980-1981), was supported by a Senior International Fellowship (F06-TW00461-01) of the Fogarty International Center, N.I.H.


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