Possibilities for breast cancer prophylaxis: Functioning peculiarities of the main regulatory systems in patients with breast precancerous conditions and breast cancer

Purpose: A comparative study of indices of the main regulatory systems in women with precancerous and cancerous lesions of the breast was conducted in order to define possible groups being at high risk for breast cancer development. Materials and methods: This study included 140 women with benign dysplasia (BD), 92 with benign tumors (fibroadenomas-FA), 108 patients with breast cancer (BC) and 40 healthy women. The functions of the vegetative nervous system (VNS), immune system and lymphocyte DNA-repair system were studied under different conditions. Results: Analysis of the obtained data showed that changes of separate parameters of homeostasis were already present in patients with BD. The sequence from BD to FA to BC is followed by a deterioration of structural and functional properties of the systems under study. Conclusion: The changes of the parameters of the main regulatory systems in patients with precancerous breast lesions can be considered as prognostic factors and may help to form groups being at high risk for breast cancer development, contributing thus to cancer prevention.