TY - JOUR
T1 - Population-Based Study of Emergence and Spread of Escherichia coli Producing OXA-48-Like Carbapenemases, Israel, 2007-2023
AU - CPE Working Group
AU - Temkin, Elizabeth
AU - Bechor, Moshe
AU - Lurie-Weinberger, Mor N.
AU - Keren-Paz, Alona
AU - Chen, Dafna
AU - Lugassy, Carmela
AU - Solter, Ester
AU - Schwaber, Mitchell J.
AU - Carmeli, Yehuda
AU - Brosh-Nissimov, Tal
AU - Sorek, Nadav
AU - Zvi, Haim Ben
AU - Chervets, Rita
AU - Wolf, Nataliya Halel
AU - Nisimov, Orli
AU - Rubinovitch, Bina
AU - Boumard, Tamar
AU - Gofaizen, Evgeniya
AU - Mendelson, Bracha
AU - Paz, Alona
AU - Sarafov, Mirit Hershman
AU - Feldman, Marina
AU - Salah, Ola
AU - Najjar-Debbiny, Ronza
AU - Avraham, Iris
AU - Strauss, Merav
AU - Chazan, Bibiana
AU - Bendahan, Tal
AU - Favor, Ayelet
AU - Gross, Ilana
AU - Harpaz, Kamy
AU - Hen, Jana
AU - Ottolenghi, Miriam
AU - Radvogin, Eleonora
AU - Reichman, Nechamat
AU - Ronen, Naama
AU - Shilo, Nehama
AU - Zahran, Shady
AU - Oster, Yonatan
AU - Fedorowsky, Rina
AU - Yerushalmi, Rebecca
AU - Gottesman, Tamar
AU - Natan, Orna Ben
AU - Ganayem, Muhammed
AU - Vaknin, Aliza
AU - Cohen, Regev
AU - Bardenstein, Rita
AU - Ciobotaro, Pnina
AU - Uliel, Chen
AU - Zayyad, Hiba
N1 - Publisher Copyright:
© 2025 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2025/1
Y1 - 2025/1
N2 - Escherichia coli producing OXA-48-like carbapenemases (OXA-EC) is considered a high-risk pathogen spread primarily in the community in low- and middleincome countries and nosocomially in high-income countries. We investigated the emergence and spread of OXA-EC in Israel, a high-income country with strong carbapenemase-directed infection control in healthcare institutions, by conducting a population-based study using data and isolates from the national surveillance system. A total of 3,510 incident cases of OXA-EC occurred during 2007-2023. During 2016-2023, annual cases rose from 41 to 1,524 and nonnosocomial cases rose from 39% to 57%. Sixty-three sequenced isolates belonged to 20 sequence types (STs) and had 3 blaOXA alleles (blaOXA-244, blaOXA-48, and blaOXA-181); 71% were chromosomally encoded, and 29% were plasmidencoded. Nosocomially and non-nosocomially acquired isolates belonged to the same STs and alleles. Most outbreaks involved multiple STs and could only partially be explained by plasmid dissemination. Measures for confronting OXA-EC might need reconsideration.
AB - Escherichia coli producing OXA-48-like carbapenemases (OXA-EC) is considered a high-risk pathogen spread primarily in the community in low- and middleincome countries and nosocomially in high-income countries. We investigated the emergence and spread of OXA-EC in Israel, a high-income country with strong carbapenemase-directed infection control in healthcare institutions, by conducting a population-based study using data and isolates from the national surveillance system. A total of 3,510 incident cases of OXA-EC occurred during 2007-2023. During 2016-2023, annual cases rose from 41 to 1,524 and nonnosocomial cases rose from 39% to 57%. Sixty-three sequenced isolates belonged to 20 sequence types (STs) and had 3 blaOXA alleles (blaOXA-244, blaOXA-48, and blaOXA-181); 71% were chromosomally encoded, and 29% were plasmidencoded. Nosocomially and non-nosocomially acquired isolates belonged to the same STs and alleles. Most outbreaks involved multiple STs and could only partially be explained by plasmid dissemination. Measures for confronting OXA-EC might need reconsideration.
UR - https://www.scopus.com/pages/publications/85213855446
U2 - 10.3201/eid3101.240722
DO - 10.3201/eid3101.240722
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 39714269
AN - SCOPUS:85213855446
SN - 1080-6040
VL - 31
SP - 66
EP - 74
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 1
ER -
SDG 3 Good Health and Well-being