Triacetonamine was used to synthesize a series of highly substituted 4-piperidones and 4-piperidols. The spatial configuration of these compounds was determined. The anionoid addition to the carbonyl group of these piperidones proceeds through highly stereoselective equatorial attack. The position of the chair-chair-twist conformational equilibrium was determined for the polysubstituted 4-piperidols.
|Number of pages||9|
|Journal||Bulletin of the Academy of Sciences of the USSR Division of Chemical Science|
|State||Published - Feb 1991|