Polysubstituted 4-piperidones and 4-piperidols: Synthesis and spatial configuration

A. M. Belostotsky, A. B. Shapiro

Research output: Contribution to journalArticlepeer-review

Abstract

Triacetonamine was used to synthesize a series of highly substituted 4-piperidones and 4-piperidols. The spatial configuration of these compounds was determined. The anionoid addition to the carbonyl group of these piperidones proceeds through highly stereoselective equatorial attack. The position of the chair-chair-twist conformational equilibrium was determined for the polysubstituted 4-piperidols.
Original languageAmerican English
Pages (from-to)421-429
JournalBulletin of the Academy of Sciences of the USSR, Division of chemical science
Volume40
Issue number2
StatePublished - 1991

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