Polysaccharide-Based Conjugates for Biomedical Applications

Arijit Basu, Konda Reddy Kunduru, Ester Abtew, Abraham J. Domb

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations

Abstract

Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, and macromolecule delivery, tissue engineering, and other biomedical applications. Polysaccharide conjugates have also been used primarily for solubilization and controlled release of hydrophobic moieties. The advent of nanotechnology, gene therapy, and tissue engineering influenced the way these conjugates are now used. Modern day conjugates are modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces different polysaccharides followed by different synthetic strategies used for conjugation; finally, recent applications were compiled.

Original languageEnglish
Pages (from-to)1396-1412
Number of pages17
JournalBioconjugate Chemistry
Volume26
Issue number8
DOIs
StatePublished - 19 Aug 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

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