Polymers in gene therapy: Antisense delivery systems

Zvi H. Israel, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Antisense aligonucleotides can down-regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. While effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non-viral methods of antisense delivery and also describes some of the exciting potential clinical applications of this technology.

Original languageEnglish
Pages (from-to)799-805
Number of pages7
JournalPolymers for Advanced Technologies
Issue number10-11
StatePublished - 1998
Externally publishedYes


  • Antisense oligonucleotides
  • Delivery systems
  • Gene therapy
  • Polymer


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