Polymers in gene therapy: Antisense delivery systems

Zvi H. Israel; Abraham J. Domb

doi:10.1002/(SICI)1099-1581(1998100)9:10/11<799::AID-PAT807>3.0.CO;2-N

Polymers in gene therapy: Antisense delivery systems

Zvi H. Israel, Abraham J. Domb

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Antisense aligonucleotides can down-regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. While effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non-viral methods of antisense delivery and also describes some of the exciting potential clinical applications of this technology.

Original language	English
Pages (from-to)	799-805
Number of pages	7
Journal	Polymers for Advanced Technologies
Volume	9
Issue number	10-11
DOIs	https://doi.org/10.1002/(SICI)1099-1581(1998100)9:10/11<799::AID-PAT807>3.0.CO;2-N
State	Published - 1998
Externally published	Yes

Keywords

Antisense oligonucleotides
Delivery systems
Gene therapy
Polymer

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10.1002/(SICI)1099-1581(1998100)9:10/11<799::AID-PAT807>3.0.CO;2-N

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Polymers in gene therapy: Antisense delivery systems

Abstract

Keywords

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