TY - JOUR
T1 - Polymerase chain reaction search for viral etiology of vulvar vestibulitis syndrome
AU - Bornstein, J.
AU - Shapiro, S.
AU - Rahat, M.
AU - Goldshmid, N.
AU - Goldik, Z.
AU - Abramovici, H.
AU - Lahat, N.
PY - 1996/7
Y1 - 1996/7
N2 - OBJECTIVE: Our purpose was to assess the prevalence of infections by human papillomavirus, herpes simplex virus, and cytomegalovirus among women with severe vulvar vestibulitis. STUDY DESIGN: Eighty-six women referred for dyspareunia and diagnosed as having severe vestibulitis underwent perineoplasty, including surgical removal of the sensitive vestibule. Controls included 25 age-matched patients without dyspareunia undergoing vaginal operations for various benign causes or undergoing repair of an episiotomy. Polymerase chain reaction analysis was carried out to determine the presence of vital genes. RESULTS: The prevalence of herpes simplex virus and cytomegalovirus among the subjects tested was nil, whereas human papillomavirus was detected in 46 cases (54%). The human papillomavirus present was not of types 6, 11, 16, 18, or 33. Only one woman of the 25 asymptomatic controls (4%) had human papillomavirus deoxyribonucleic acid in the vestibule (p < 0.001). CONCLUSION: Our data provide support for the idea that vulvar vestibulitis is associated with human papillomavirus deoxyribonucleic acid in more than half of cases.
AB - OBJECTIVE: Our purpose was to assess the prevalence of infections by human papillomavirus, herpes simplex virus, and cytomegalovirus among women with severe vulvar vestibulitis. STUDY DESIGN: Eighty-six women referred for dyspareunia and diagnosed as having severe vestibulitis underwent perineoplasty, including surgical removal of the sensitive vestibule. Controls included 25 age-matched patients without dyspareunia undergoing vaginal operations for various benign causes or undergoing repair of an episiotomy. Polymerase chain reaction analysis was carried out to determine the presence of vital genes. RESULTS: The prevalence of herpes simplex virus and cytomegalovirus among the subjects tested was nil, whereas human papillomavirus was detected in 46 cases (54%). The human papillomavirus present was not of types 6, 11, 16, 18, or 33. Only one woman of the 25 asymptomatic controls (4%) had human papillomavirus deoxyribonucleic acid in the vestibule (p < 0.001). CONCLUSION: Our data provide support for the idea that vulvar vestibulitis is associated with human papillomavirus deoxyribonucleic acid in more than half of cases.
KW - Vulvar vestibulitis
KW - cytomegalovirus
KW - herpes simplex virus
KW - human papillomavirus
KW - perineoplasty
KW - polymerase chain reaction
KW - vulvodynia
UR - http://www.scopus.com/inward/record.url?scp=0029812017&partnerID=8YFLogxK
U2 - 10.1016/s0002-9378(96)70263-6
DO - 10.1016/s0002-9378(96)70263-6
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C2 - 8694039
AN - SCOPUS:0029812017
SN - 0002-9378
VL - 175
SP - 139
EP - 144
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -