Poly(lactic acid) based hydrogels

Arijit Basu, Konda Reddy Kunduru, Sindhu Doppalapudi, Abraham J. Domb, Wahid Khan

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations

Abstract

Polylactide (PLA) and its copolymers are hydrophobic polyesters used for biomedical applications. Hydrogel medicinal implants have been used as drug delivery vehicles and scaffolds for tissue engineering, tissue augmentation and more. Since lactides are non-functional, they are copolymerized with hydrophilic monomers or conjugated to a hydrophilic moiety to form hydrogels. Copolymers of lactic and glycolic acids with poly(ethylene glycol) (PEG) provide thermo-responsive hydrogels. Physical crosslinking mechanisms of PEG–PLA or PLA-polysaccharides include: lactic acid segment hydrophobic interactions, stereocomplexation of D and L-lactic acid segments, ionic interactions, and chemical bond formation by radical or photo crosslinking. These hydrogels may also be tailored as stimulus responsive (pH, photo, or redox). PLA and its copolymers have also been polymerized to include urethane bonds to fabricate shape memory hydrogels. This review focuses on the synthesis, characterization, and applications of PLA containing hydrogels.

Original languageEnglish
Pages (from-to)192-205
Number of pages14
JournalAdvanced Drug Delivery Reviews
Volume107
DOIs
StatePublished - 15 Dec 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

  • Hydrogel
  • In situ hydrogel
  • PLA
  • PLA–PEG
  • Responsive polymer
  • Thermo-responsive

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