Poly(ester anhydride)s prepared by the insertion of ricinoleic acid into poly(sebacic acid)

Michal Y. Krasko, Ariella Shikanov, Aviva Ezra, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

New degradable poly(ester anhydride)s were prepared by the melt polycondensation of diacid oligomers of poly(sebacic acid) (PSA) transesterified with ricinoleic acid. The transesterification of PSA with ricinoleic acid to form oligomers was conducted via a melt bulk reaction between a high molecular weight PSA and ricinoleic acid. A systematic study on the synthesis, characterization, degradation in vitro, drug release, and stability of these polymers was performed. Polymers with weight-average molecular weights of 2000-60,000 and melting temperatures of 24-77 °C were obtained for PSA containing 20-90% (w/w) ricinoleic acid. NMR and IR analyses indicated the formation of ester bonds along the polyanhydride backbone. These new degradable copolymers have potential use as drug carriers.

Original languageEnglish
Pages (from-to)1059-1069
Number of pages11
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume41
Issue number8
DOIs
StatePublished - 15 Apr 2003
Externally publishedYes

Keywords

  • Biodegradable
  • Drug delivery systems
  • Implant
  • Poly(ester anhydride)s
  • Transesterification

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