Abstract
Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days.
| Original language | English |
|---|---|
| Pages (from-to) | 127-139 |
| Number of pages | 13 |
| Journal | Journal of Bioactive and Compatible Polymers |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Mar 2016 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© SAGE Publications.
Keywords
- Drug delivery
- gentamicin
- poly(ester-anhydride)
- ricinoleic acid
- sebacic acid
- thyrotropin-releasing hormone
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