Polyanhydrides with hydrophobic terminals

Michal Y. Krasko, Ariella Shikanov, Neeraj Kumar, Abraham J. Domb

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16 Scopus citations


Polyanhydrides prepared from hydrophobic diacids such as sebacic acid (SA) are brittle and unstable in storage and degrade with time. The physical properties of these polyanhydrides have been improved by introducing hydrophobic terminals into the main chain which has provided better stability and controlled the molecular weight. The effects of molecular weight, pliability, biodegration and drug release on polymer were investigated. Poly(sebacic anhydride) (PSA) was terminated with the unsaturated fatty acids, ricinoleic acid, oleic acid, linoleic acid and the cholesterol derivative, lithocholic acid, and prepared in the weight ratio of 70:30. Polymers thus obtained had a predictable molecular weight of 3-8 _xt 103 and an Mp of 60-76°C and degraded at the rate of 3.3-7.6 mg/cm2/day. The rate of degradation was dependent on the contents of the hydrophobic terminals. These polyanhydrides were found to be useful for the release of hydrophobic and hydrophilic drugs for 2-3 weeks in vitro.

Original languageEnglish
Pages (from-to)960-968
Number of pages9
JournalPolymers for Advanced Technologies
Issue number10-12
StatePublished - 2002
Externally publishedYes


  • Biodegradable polymers
  • Drug release
  • Fatty acids
  • Polyanhydrides
  • Termination


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